首页|参麦注射液对乳腺癌晚期放疗肺损伤的保护作用研究

参麦注射液对乳腺癌晚期放疗肺损伤的保护作用研究

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目的 探讨参麦注射液对乳腺癌晚期放疗肺损伤的保护作用机制研究.方法 选取2015年1月至2016年5月于本院以乳腺癌晚期放疗后肺损伤为诊断入院的患者80例,随机分为2组:对照组40例,予常规治疗;实验组40例,在对照组的治疗基础上加用参麦注射液治疗.共治疗4周.观察2组患者治疗前后肺功能、T淋巴细胞亚群、临床症状、生活质量评分水平以及临床疗效,其结果采用统计学软件SPSS 19.0进行数据分析.结果 与治疗前比较,2组患者治疗后的FVC、FEV1以及TLC水平均明显升高,呼吸系统症状、活动能力以及日常生活影响评分明显降低,血清CD3+、CD4+、CD4+/CD8+水平均有升高,CD8+水平均降低;治疗后与对照组比较,实验组FVC(84.65±12.35)、FEV1(92.15±13.01)、TLC(88.13±11.36)、CD3+(57.29±7.39)、CD4+(41.29±6.15)、CD4+/CD8+(1.54±0.22)水平,均明显高对照组FVC(79.11±8.1)、FEV1(83.28±12.34)、TLC(81.16±10.33)、CD3+(53.77±6.28)、CD4+(38.21±5.33)、CD4+/CD8+(1.36±0.18)水平,CD8+(25.12±4.39)水平明显低于对照组CD8+(27.28±4.29)水平,临床总有效率(52.5%)高于对照组(27.5%),以上结果差异均有统计学意义(P<0.05).结论 参麦注射液能有效提高乳腺癌晚期放疗肺损伤患者的肺功能和免疫力,改善呼吸系统症状,提高生存质量,且具有较好的临床疗效.
Protective effect of Shen Mai injection in the treatment of lung injury induced by radiotherapy in patients with advanced breast cancer
Objective To investigate the protective effect of Shen Mai injection in the treatment of lung injury induced by radiotherapy in patients with advanced breast cancer. Methods 80 cases with lung injury induced by radiotherapy in patients with advanced breast cancer from our hospital from 2015.1 to 2016.5 were selected and randomly divided into 2 groups, 40 cases in control group were given routine treatment, 40 cases in the experimental group were treated based on the control group treated with Shenmai injection treatment, and 2 groups were treated for 4 weeks. The pulmonary function, T lymphocyte subsets, clinical symptoms, quality of life scores and clinical efficacy were observed before and after treatment in two groups. The results were analyzed by statistical software SPSS 19.0. Results Compared with before treatment, levels of FVC, FEV1 and TLC in 2 groups after treatment elevated, scores of respiratory symptoms, activities, and daily life effect decreased, levels of serum CD3+, CD4+, CD4+/CD8+elevated, levels of CD8+ decreased, and compared with the control group, levels of FVC, FEV1, TLC, CD3+, CD4+, CD4+/CD8+ in the experimental group were higher, scores of respiratory symptoms, activities, and daily life effect were lower, clinical effect rate was higher, the differences were statistically significant (P<0.05). Conclusion Shen Mai injection can effectively improve lung function and immunity, improve respiratory symptoms and improve the quality of life in patients with advanced breast cancer radiotherapy for lung injury, and has better clinical efficacy.

Shen Mai injectionbreast cancerlung functionT lymphocyte subsets

何伟岳、陆启轮、黄昌靖

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舟山医院 放疗科,浙江 舟山 316004

湖北工业大学 生物工程学院,湖北 武汉 430068

参麦注射液 乳腺癌 肺功能 T淋巴细胞亚群

2017

10.3969/j.issn.1005-1678.2017.01.025

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN：1005-1678
年,卷(期)：2017.37(1)
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