摘要
目的 探究补肾健骨胶囊对类风湿关节炎患者类风湿因子(Rheumatoid factor,RF)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、红细胞沉降率(Erythrocyte sedimentation rate,ESR)的影响.方法 94例类风湿关节炎患者按抽签法分为对照组与研究组,各47例,对照组采用传统西医治疗,研究组基于对照组加用补肾健骨胶囊,比较2组RF、hs-CRP、ESR,免疫球蛋白A、M、G(IgA、IgM、IgG,密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、甘油三酯(TG)、总胆固醇(TC),关节肿胀数、关节压痛数、晨僵时间,疗效和不良反应.结果 治疗后,实验组RF、hs-CRP、ESR低于对照组(57.53±8.13)U/L、(6.30±0.78)mg/L、(21.48±3.03)mm/h比(74.29±10.56)U/L、(13.14±1.86)mg/L、(35.60±4.36)mm/h,比较有统计学差异(P<0.05).实验组IgA、IgM、IgG、HDL-C、LDL-C、TG、TC、关节肿胀数、关节压痛数、晨僵时间均优于对照组(2.17±0.29)g/L、(1.53±0.21)g/L、(12.14±1.50)g/L、(1.25±0.15)mmol/L(2.11±0.26)mmol/L、(1.34±0.17)mmol/L、(4.03±0.50)mmol/L、(4.35±0.53)个、(6.30±0.77)个、(29.71±3.70)min比(2.30±0.28)g/L、(2.11±0.26)g/L、(13.76±1.70)g/L、(1.16±0.14)mmol/L(2.29±0.28)mmol/L、(1.53±0.19)mmol/L、(4.50±0.55)mmol/L、(7.63±0.96)个、(8.51±1.21)个、(76.38±9.50)min(P<0.05).实验组总有效率高于对照组(93.61%比76.59%)(P<0.05).比较2组不良反应无差异.结论 补肾健骨胶囊治疗类风湿关节炎的效果肯定,可降低RF、hs-CRP、ESR水平.
Abstract
Objective To analyze the influence of Bushenjiangu Capsules on rheumatoid factor (RF), hypersensitive c-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR) with rheumatoid arthritis patients. Methods 94 patients with rheumatoid arthritis in the draw method was divided into control group and experimental group the 47 cases, control group treatmented by conventional western medicine, the experimental group based on the control group treatmented by Bushenjiangu Capsules, two groups' of RF, hs-CRP, ESR, Immunoglobulin A, M, G (IgA, IgM and IgG immune globulin), density lipoprotein (HDL-C), low density lipoprotein (LDL- C), triglyceride (TG), total cholesterol (TC), blood lipid, joint swelling, joint tenderness, morning stiffness time, curative effect and adverse reactions were compared. Results After treatmented, the RF, hs-CRP, ESR of experimental group was lower than the control group (57.53±8.13) U/L, (6.30±0.78) mg/L, (21.48±3.03) mm/h vs (74.29±10.56) U/L, (13.14±1.86 )mg/L, (35.60±4.36) mm/h, the difference was statistically significant (P<0.05). The IgA, IgM and IgG, HDL, LDL - C - C, TG, TC, joint swelling count, joint tenderness, morning stiffness time of experimental group was better than control group (2.17±0.29) g/L, (1.53±0.21) g/L, (12.14±1.50) g/L, (1.25±0.15)mmol/L (2.11 ±0.26) mmol/L, (1.34±0.17) mmol/L, (4.03±0.50) mmol/L, (4.35±0.53), (6.30±0.77), (29.71±3.70) min than g/L (2.30±0.28), (2.11±0.26) g/L, (13.76±1.70) g/L, (1.16±0.14) mmol/L (2.29±0.28) mmol/L, (1.53±0.19) mmol/L, (4.50±0.55) mmol/L, (7.63±0.96), (8.51±1.21), (76.38±9.50) min (P<0.05). The total effective rate of experimental group was higher than the control group (93.61%vs 76.59%) (P<0.05).The adverse reaction of two groups was no difference. Conclusion The effect is sure of Bushenjiangu capsule treatment of rheumatoid arthritis, can reduce the levels of RF, hs-CRP, ESR.
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维普
万方数据