摘要
目的 探讨成纤维细胞生长因子对2型糖尿病患者拔牙并发感染的预防作用.方法 本研究中用碱性成纤维细胞因子进行感染预防的患者76例,对照组90例患者,患牙总颗数324颗.干预组接受碱性成纤维细胞生长因子预防处理,使用重组牛碱性成纤维细胞生长因子凝胶进行预防,常规处理组使用常规漱口液进行消毒预防感染.随访观察1w后感染情况.结果 使用碱性成纤维细胞因子组术后随访一周有2例患者出现感染,感染率2.63%,低于对照组,但无统计学差异.同时测定感染相关基础指标,使用碱性成纤维细胞因子组术后1w白细胞总数(6.67±1.08)×109/L,显著低于对照组(P<0.05).CRP水平为(90.33±12.95)mg/L,也显著低于对照组水平(P<0.05).男性中使用碱性成纤维细胞因子组感染发生率为2.7%,对照组为6.38%,虽然未发现统计学差别,但是2组患者的白细胞总数和CRP水平差异明显(P<0.05),使用碱性成纤维细胞因子进行感染预防干预组的白细胞总数和CRP水平均显著低于对照组的水平(P<0.05).在女性中也发现了类似的结果.结论 牙齿拔除手术后,预防术后感染,进而预防控制干槽症等的发生,应用成纤维细胞生长因子取得了满意的效果.
Abstract
Objective To investigate the preventive effect of fibroblast growth factor on infection after tooth extraction among type 2 diabetes mellitus patients. Methods 76 patients with infection prevention were treated with basic fibroblast growth factor, and 90 patients in the control group(n= 324). The intervention group was treated with basic fibroblast growth factor and treated with recombinant bovine basic fibroblast growth factor gel. The routine treatment group was treated with routine rinsing liquid for disinfection to prevent infection. Follow-up observation of infection after 1 week. Results In the group of basic fibroblast growth factor, the infectious rate was 2.63%, which was not significantly lower than that of the control group. The level of white blood cells in the group treated with basic fibroblast factor was (6.67±1.08)×109/L, which was significantly lower than that of the control group. The CRP level was (90.33±12.95) mg/L, which was significantly lower than that of the control group Group level (P<0.05). The incidence of fibroblast infection was 2.7% in men and 6.38% in control group. Although there was no significant difference between the two groups, the difference in the total WBC count and CRP level between the two groups was significant different (P<0.05). The group which use of basic fibroblast growth factor, the total white blood cell count and CRP level of the infection prevention intervention group were significantly lower than the control group (P<0.05). Similar results were found in women. Conclusion Fibroblast growth factor can be used to prevent postoperative infection, and achieve satisfactory results.
NETL
NSTL
维普
万方数据