聚乙二醇干扰素α-2a结合利巴韦林治疗1b型慢性丙型病毒性肝炎的效果
Effect of PEG-IFN alpha -2a combined with ribavirin in type 1b chronic hepatitis C virus
宋玉龙 1侯伟 1金茜1
作者信息
- 1. 浙江省台州学院附属台州市立医院 感染科,浙江 台州 318000
- 折叠
摘要
目的 探讨聚乙二醇干扰素α-2a(peginterferon alfa-2a injection,PEG-IFNα-2a)结合利巴韦林(ribavirin,RBV)对1b型慢性丙型病毒性肝炎的治疗效果.方法 回顾性分析2010年5月~2015年10月在浙江省台州学院附属台州市立医院感染科接受治疗的1b型慢性丙型病毒性肝炎患者的临床资料.根据其治疗方式分为干扰素α-2a(IFNα-2a)联合利巴韦林组与PEG-IFNα-2a联合利巴韦林组.观察2组患者获得的快速病毒学应答(rapid virologic response,RVR)、早期病毒学应答(early virologic response,EVR)、持续病毒学应答(sustained virologic response,SVR)率,比较2组治疗前后肝功能、外周血CD4+T细胞和CD8+T细胞表达情况以及不良反应发生率的差异.结果 2组RVR、EVR、SVR获得率无明显差异(χ2=0.641、0.946、0.154,P=0.423、0.331、0.694).2组治疗后,PEG-IFNα-2a联合利巴韦林组的丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、直接胆红素(direct bilirubin,DBIL)和总胆红素(total bilirubin,TBIL)水平低于IFNα-2a联合利巴韦林组(P<0.05).2组治疗后,PEG-IFNα-2a联合利巴韦林组的CD4+T水平低于IFNα-2a联合利巴韦林组,CD8+T水平高于IFNα-2a联合利巴韦林组(P<0.05).2组流感样症状、骨髓抑制、嗜睡和实验室指标异常发生率无明显差异.结论 PEG-IFNα-2a结合RBV对1b型慢性丙型病毒性肝炎有较好的治疗效果,且安全性好.
Abstract
Objective To investigate the effect of peginterferon alfa-2a injection (PEG-IFNα-2a) combined with ribavirin (RBV) in the treatment of chronic hepatitis C virus (1b) in patients with chronic hepatitis C. Methods The clinical data of patients with type 1b chronic hepatitis C in our hospital from May 2010 to October 2015 were retrospectively analyzed. According to the method of treatment, the patients were divided into IFNα-2a combined with RBV group and PEG-IFNα-2a combined with RBV group. The rapid virologic response (RVR), early virologic response (EVR), and sustained virologic response (SVR) rate were observed in the two groups. The liver function, expressions of CD4+T and CD8+T cell of peripheral blood and the incidence of adverse reaction were compared between the two groups before and after treatment. Results The RVR, EVR, SVR of two groups was no significant difference (χ2=0.641, 0.946, 0.154, P=0.423, 0.331, 0.694). After treatment, the levels of ALT , AST, DBIL and TBIL in PEG-IFNα-2a combined with RBV group were lower than those in IFNα-2a combined with RBV group (P<0.05). Of the PEG-IFNα-2a combined with RBV group, the CD4+T level was lower and the CD8+T level was higher than that in PEG-IFNα-2a in the combined Leigh Bhave Lin group were lower than that in the IFNα-2a level was lower IFNα-2a combined with RBV group(P<0.05). There was no significant difference in the incidence of influenza-like symptoms, marrow suppression, somnolence and abnormal laboratory indexes between two groups. Conclusion PEG-IFN alpha -2a combined with RBV has a good therapeutic effect on type 1b chronic hepatitis C virus, and has good safety and clinical application value.
关键词
聚乙二醇干扰素α-2a/1b型慢性丙型病毒性肝炎/利巴韦林/肝功能Key words
PEG-IFNα-2a/1b chronic hepatitis C/ribavirin/liver function引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据