17β-雌二醇治疗围绝经期特发性室性心律失常疗效及对钙离子库受体IP3/Ryn 2基因表达的影响
Effect of 17β-estradiol on idiopathic ventricular arrhythmia and IP3/Ryn 2 expression of receptor-regulated calcium pool during peri-menopausal period
童玲 1危先江 2林春香1
作者信息
- 1. 杭州市西溪医院 妇产科,浙江 杭州 310023
- 2. 杭州市红十字医院 妇产科,浙江 杭州 310000
- 折叠
摘要
目的 观察17β-雌二醇治疗围绝经期特发性室性心律失常(idiopathic ventricular arrhythmia,IVA)临床疗效并研究其对钙离子库受体IP3/Ryn 2基因表达的影响,推断2者之间的关联性.方法 选择围绝经期特发性室性心律失常患者32例,同时选择32例同龄的围绝经期正常女性作为正常对照组.围绝经期IVA患者连续口服17β-雌二醇2个月.观察围绝经期IVA患者应用17β-雌二醇前后心律失常计数变化情况;检测围绝经期IVA患者治疗前、治疗后、正常对照者外周血钙离子库受体IP3和Ryn 2基因表达.结果 围绝经期特发性室性心律失常患者经17β-雌二醇治疗后室性心律失常计数较治疗前明显减少(P<0.05).与治疗前比较,经17β-雌二醇治疗后IP3基因表达明显下降(P<0.05),且同正常对照组相比无统计学意义.17β-雌二醇对Ryn 2受体基因表达无明显影响.结论 17β-雌二醇抑制特发性室性心律失常可能与钙离子库受体IP3基因表达相关.
Abstract
Objective To observe the curative effect of 17β-estradiol on idiopathic ventricular arrhythmia (IVA) during peri-menopausal period and explore the association with IP3/Ryn expression of receptor-regulated calcium pool. Methods 32 cases IVA during peri-menopausal period (IVA group) and 32 cases healthy women during peri-menopausal period of the same levels of age (normal control group) were selected. The IVA group received oral 17β-estradiol for 2 months. The count of arrhythmia in IVA group was recorded, the IP3/Ryn 2 expression pre- and post-treatment in IVA group and normal control group were detected. Results Compared with pre-treatment, 17β-estradiol significantly reduced the occurrence of IVA (P<0.05). Compared with pre-treatment, 17β-estradiol significantly reduced IP3 expression(P<0.05), while there was no significant difference compared with normal control group. 17β-estradiol had no significant effect on Ryn 2 expression. Conclusion The anti-IVA effect of 17β-estradiol may be associated with the IP3 receptor gene expression.
关键词
17β-雌二醇/围绝经期/特发性室性心律失常/IP3基因/Ryn2基因Key words
17β-estradiol/peri-menopausal period/idiopathic ventricular arrhythmia/IP3/Ryn 2引用本文复制引用
出版年
2017
NETL
NSTL
万方数据