胰激肽原酶肠溶片对糖尿病视网膜病变患者视盘及黄斑部视网膜血流动力学的影响
Effects of pancreatic kininogenase enteric-coated tablets on optic discand macular retinal hemodynamics in diabetic retinopathy
蔡锋 1曾志红 1徐冬梅 1刘少琴 1吴林丽1
作者信息
- 1. 龙泉市人民医院 内分泌科,浙江 丽水 323700
- 折叠
摘要
目的 探讨胰激肽原酶肠溶片治疗糖尿病视网膜病变(diabetic retinopathy,DR)患者的效果及对视盘及黄斑部视网膜血流动力学的影响.方法 86例(140眼)DR患者,采用随机数字表法分为胰激肽原酶组和常规组各43例,2组均采用基础性疗法,胰激肽原酶组同时加用胰激肽原酶治疗,对比2组最佳矫正视力、临床效果及视盘及黄斑部视网膜血流动力学变化.结果 治疗后,胰激肽原酶组的最佳矫正视力(best corrected visual acuity,BCVA)值大于常规组(P<0.05),胰激肽原酶组的视网膜新生血管荧光素渗漏面积小于常规组(P<0.05),胰激肽原酶组视盘大血管及黄斑部视网膜的血流量、血流速度测定值均大于常规组,胰激肽原酶组的临床疗效优于常规组(P<0.05).结论 胰激肽原酶肠溶片治疗DR患者有利于改善视盘及黄斑部视网膜血流参数、提升患者视力、减少视网膜新生血管荧光素渗漏面积,从而提高临床治疗效果.
Abstract
Objective To explore the pancreatic kininogenase enteric-coated tablets in the treatment of diabetic retinopathy (DR) patients and its effect on the optic disc and macula retinal hemodynamics. Methods 86 cases (140 eyes) of DR patients were randomly divided into pancreatic kininogenase group and normal group with 43 cases in each group, two groups were treated with basic therapy, pancreatic kininogenase group were combined with pancreatic kininogenase treatment. The best corrected visual acuity and the clinical effect of optic disc and macula retinal hemodynamic changes were compared between two groups. Results After treatment, the best corrected visual acuity (BCVA) in pancreatic kininogenase group was greater than the normal group (P<0.05), the retinal neovascularization and fluorescein leakage area in pancreatic kininogenase group was less than the normal group (P<0.05). The disc vascular and macular retinal blood flow volume (VOL), blood flow velocity (FLW)values in pancreatic kininogenase group were larger than those of normal group, and the clinical curative effect of pancreatic kininogenase group was better than that of normal group (P<0.05). Conclusion Pancreatic kininogenase enteric-coated tablets in the treatment of DR patients can improve the optic disc and macular retinal hemodynamic parameters, improve visual acuity and reduce the retinal neovascularization and fluorescein leakage area, so as to improve the clinical treatment effect.
关键词
胰激肽原酶/糖尿病视网膜病变/视盘/黄斑部/视网膜/血流动力学Key words
pancreatic kininogenase/diabetic retinopathy/optic disc/macular/retina/hemodynamics引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据