首页|布地奈德与沙丁胺醇对支气管肺炎患者血清IL-6、TNF-α的影响

布地奈德与沙丁胺醇对支气管肺炎患者血清IL-6、TNF-α的影响

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目的 探讨布地奈德联合沙丁胺醇治疗支气管肺炎患者的治疗效果及血清白细胞介素-6(interleukin,IL-6)、肿瘤坏死因子-α(tumor necrosis factorα,TNF-α)的影响作用.方法 选取110例支气管肺炎患者,采用随机数字表法分为研究组、常规组各55例,2组均给予抗炎、吸氧及对症处理,研究组同时加用布地奈德联合沙丁胺醇治疗,对比2组疗效及血清IL-6、TNF-α水平变化.结果 研究组的咳嗽、发热、气促、肺部干湿罗音的消失时间、住院时间均显著的短于常规组,差异具有统计学意义(P<0.05).治疗5d后,研究组的血清IL-6、TNF-α水平均低于常规组(P<0.05),研究组的动脉血氧分压(PaO2)、动脉血氧饱和度(SaO2)水平均高于常规组(P<0.05);治疗5d后,研究组治愈率74.55%、好转率23.64%、无效率1.82%,常规组治愈率54.55%、好转率40.00%、无效率5.45%,2组比较差异具有统计学意义(P<0.05).结论 布地奈德联合沙丁胺醇治疗支气管肺炎患者有利于进一步提高抗炎效果、改善患者的临床症状,从而达到缩短治疗时间及提高临床疗效的目的.
Effect of budesonide and salbutamol on serum IL-6 and TNF- levels in bronchopneumonia
Objective To explore the therapeutic effect of budesonide combined with salbutamol on serum interleukin (IL-6) and tumor necrosis factorα (TNF-α) in treatment of bronchial pneumonia. Methods A total of 110 cases of bronchial pneumonia patients were randomly divided into the study group and the normal group, with 55 cases in each group, the two groups were given oxygen, anti-inflammatory and symptomatic treatment, the study group received budesonide combined with salbutamol treatment, the curative effect and changes of serum IL-6, TNF-alpha levels were compared between two groups. Results The disappeared time of cough, fever, shortness of breath,rhonchi and moist rales, hospitalization time in study group were significantly shorter than the conventional group, the difference was statistically significant (P<0.05). After 5 days' treatment, the serum IL-6, TNF-α in study group were lower than normal group(P<0.05), the PaO2, SaO2 in study group were higher than normal group (P<0.05). The efficacy in study group was higher than normal group (P<0.05). Conclusion Budesonide combined with salbutamol in treatment of bronchial pneumonia patients could improve clinical symptoms and anti-inflammatory effect, so as to shorten the treatment time and improve the clinical effect.

budesonidesalbutamolbronchopneumoniainterleukin -6tumor necrosis factor alpha

杨欢欢、俞宁宁

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温州市中西医结合医院 呼吸内科,浙江 温州 325000

布地奈德 沙丁胺醇 支气管肺炎 白细胞介素-6 肿瘤坏死因子-α

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(1)
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