复方氟米松软膏和丙酸氯倍他索乳膏对湿疹患者血清及皮损Th细胞相关细胞因子的影响比较
Comparison of compound flumethasone ointment and clobetasol propionate cream on serum and skin lesion Th cell related cytokines secreted in eczema
邱阳 1李思彤 2朱定仙 3方红3
作者信息
- 1. 辽宁华兴机电有限公司华兴医院 皮肤科,辽宁 锦州 121000
- 2. 杭州艺星医疗美容医院 皮肤科,浙江 杭州 310000
- 3. 浙江大学第一附属医院 皮肤科,浙江 杭州 310000
- 折叠
摘要
目的 复方氟米松软膏和丙酸氯倍他索乳膏对湿疹患者血清及皮损Th细胞相关细胞因子的影响比较.方法 回顾性选取156例慢性湿疹病患,根据外用药物种类分为氟米松组和丙酸氯倍他索组,对比2组湿疹的治疗效果、血清和皮损的Th细胞相关细胞因子的变化.结果 治疗后,氟米松组血清干扰素-γ(interferon-γ,INF-γ)为(27.57±5.67)pg/mL、白介素-2(interleukin 2,IL-2)为(36.51±8.03)pg/mL、IL-4为26.37±5.29)pg/mL、IL-10为(25.38±4.64)pg/mL和皮损INF-γ为(56.53±21.81)pg/L、IL-2为(51.69±15.67)pg/L、IL-4为(159.42±25.64)pg/L、IL-10为(139.62±24.58)pg/L显著低于丙酸氯倍他索组(P<0.05),但临床受益率(94.87%)明显高于丙酸氯倍他索组(80.77%)(P<0.05).结论 与丙酸氯倍他索乳膏相比,复方氟米松软膏治疗湿疹的效果更佳,其作用机制可能为调节Th细胞相关细胞因子表达.
Abstract
Objective To compare the effect of compound flumethasone ointment and clobetasol propionate cream on serum and skin lesion Th cell related indicators in patients with eczema. Methods 156 patients with chronic eczema were chosen. According to the type of topical drugs, they were divided into two groups: the flumethasone group and the clobetasol propionate group. The changes of eczema treatment effect, serum and skin lesions Th cell related indicators of the two groups were compared. Results After treatment, the serum interferon-γ (IFN-γ) of the flumethasone group was (27.57 ± 5.67) pg/mL, IL-2 was (36.51 ± 8.03) pg/mL and IL-4 was (26.37 ± 5.29) pg/mL, IL-10 was (25.38 ± 4.64) pg/mL and INF-γof skin lesions was (56.53 ± 21.81) pg/L , IL-2 was (51.69 ± 15.67) pg/L, IL-4 was (159.42 ± 25.64) pg/L and (139.62 ± 24.58) pg/L, significantly lower than those of clobetasol propionate group (P <0.05), but the clinical benefit rate (94.87%) was significantly higher than (80.77%) of clobetasol propionate group (P <0.05). Conclusion Compared with clobetasol propionate cream, the effect of compound flumetasone ointment is more effective in treating eczema, and its mechanism may regulate the expressions of Th cell related cytokines.
关键词
复方氟米松软膏/丙酸氯倍他索乳膏/湿疹/Th细胞相关细胞因子Key words
compound flumetasone ointment/clobetasol propionate cream/eczema/Th cell related cytokines引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据