曲伏前列腺素滴眼液对抗青光眼术后视功能、泪膜稳定性及炎症指标的影响

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中文摘要：目的研究曲伏前列腺素滴眼液对抗青光眼术后视功能、泪膜稳定性及炎症指标的影响.方法选取2014年8月~2015年8月浙江省宁海县第一医院接诊的90例已行抗青光眼患者作为本次研究对象.对照组采用马来酸噻吗洛尔治疗,观察组采用曲伏前列腺素滴眼液,观察2组患者治疗后视力、眼压情况,泪膜稳定性(破裂时间、基础泪液分泌),炎症反应(闪光、细胞计数),视野缺损范围,治疗疗效.结果治疗后,观察组视力(0.95±0.26)D优于对照组的(0.76±0.21)D,观察组眼压(11.29±3.23)mmHg小于对照组(13.89±3.72)mmHg,差异有统计学意义(P<0.05);观察组破裂时间(12.93±1.90)s大于对照组的(10.36±1.80)s、观察组基础泪液分泌(13.01±1.60)mm大于对照组的(11.10±1.02)mm,差异有统计学意义(P<0.05);观察组肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)均小于对照组,差异有统计学意义(P<0.05);观察组视野缺损(38.96±10.21)%小于对照组(47.37±11.35)%,差异有统计学意义(P<0.05);观察组总有效95.56%(43/45)高于对照组的77.78%(35/45),差异有统计学意义(P<0.05).结论曲伏前列腺素滴眼液能够改善患者抗青光眼术后视功能、泪膜稳定性,降低炎症反应.

外文标题：Effect of travoprost eye drops on visual function, stability of tear film and inflammatory index after anti-glaucoma surgery

外文摘要：Objective To study influence of travoprost eye drops in treatment of after anti-glaucoma surgery and its effects on visual function, the tear film stability and inflammatory index. Methods 90 patients of anti glaucoma who received therapy from August 2014 to August 2015 in the first hospital of Ninghai County Zhejiang Province were selected as research objects. The control group was treated with timolol maleate, while the observation group was treated with travoprost eye drops, then the visual acuity, intraocular pressure, tear film stability (rupture time, schirmer), inflammation (flashlight, cell count), visual field defect percentage range, curative effect after treatment were compared. Results After treatment, the vision in observation group (0.95±0.26)D was better than the control group (0.76±0.21)D, intraocular pressure in observation group (11.29±3.23) mmHg was less than the control group (13.89±3.72)mmHg, the difference was statistically significant (P<0.05), rupture time in observation group (12.93±1.90)s was higher than the control group (10.36±1.80)s, schirmer in observation group (13.01±1.60)mm was higher than the control group (11.10±1.02)mm, the difference was statistically significant (P<0.05), TNF-α, IL-6 in observation group was less than the control group, the difference was statistically significant (P<0.05), field of visual field defect in observation group (38.96±10.21)% was less than the control group (47.37±11.35)%, the difference was statistically significant (P<0.05), the total effective rate of observation group 95.56%(43/45) was statistically higher than that in the control group 77.78%(35/45), the difference was statistically significant (P<0.05). Conclusion Travoprost eye drops can improve glaucoma postoperative visual function, tear film stability, reduce inflammation.

外文关键词：

travoprost eye dropsglaucomavisual functionthe tear film stabilityinflammatory index

作者：

娄启阳、马小兵、孙静辉

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作者单位：

浙江省宁海县第一医院眼科,浙江宁海 315600

关键词：

曲伏前列腺素滴眼液青光眼视功能泪膜稳定性炎症指标

出版年：

2017

DOI：