小剂量阿司匹林结合美托洛尔对老年心衰患者血液高凝及心功能的改善作用
Effect of low-dose aspirin combined with metoprolol in high blood coagulation and cardiac function of elderly patients with heart failure
葛晓平 1杨俊1
作者信息
- 1. 浙江金华广福医院 心内科,浙江 金华 321000
- 折叠
摘要
目的 探讨小剂量阿司匹林结合美托洛尔对老年心衰患者血液高凝及心功能的改善作用.方法 选取浙江金华广福医院于2014年2月~2016年2月收治的老年心衰患者112例,依据随机数字表法将这些患者分为常规治疗组和联合治疗组(常规治疗基础上小剂量阿司匹林结合美托洛尔治疗组)2组,每组各56例.常规治疗组给予常规治疗,联合治疗组给予常规治疗基础上小剂量阿司匹林结合美托洛尔治疗.对2组患者的血浆P-选择素(P-selectin)、血管性假血友病因子(von willebrand factor,VWF)、血浆D-二聚体(D-dimer,D-D)、脑利钠钛(brain natriuretic peptide,BNP)水平、心率(heart rate,HR)、左心室舒张末期容积(left ventricular end-diastolic volume,LVEDV)、左室射血分数(left ventricular ejection fractions,LVEF)及临床疗效进行统计分析.结果 联合治疗组患者的血浆P-selectin、VWF、D-D、BNP水平均显著低于常规治疗组,差异有统计学意义(P<0.05),治疗的总有效率89.3%(50/56)显著高于常规治疗组78.6%(44/56),差异有统计学意义(P<0.05),但2组患者的HR、LVEDV、LVEF之间的差异均不显著.结论 小剂量阿司匹林结合美托洛尔能够有效改善老年心衰患者血液高凝及心功能.
Abstract
Objective To investigate the improvement role of low-dose aspirin combined with metoprolol in high blood coagulation and cardiac function of elderly patients with heart failure. Methods 112 cases of elderly patients with heart failure who were treated in our hospital from February 2014 to February 2016 were selected, these patients were randomly divided into conventional therapy group and combined treatment group (conventional therapy combined with low-dose aspirin beauty metoprolol treatment group) two groups, 56 cases in each group. Conventional therapy group was given routine treatment, combined treatment group wered treated on the basis of conventional therapy combined with metoprolol in the treatment of low-dose of aspirin. The plasma P-selectin, VWF, DD, BNP levels, HR, LVEDV, LVEF and clinical efficacy of the two groups were statistically analyzed. Results The P-selectin, VWF, DD, BNP levels of the combined treatment group were significantly lower than those in the conventional treatment group, the difference was statistically significant (P<0.05), the total treatment effective rate 89.3% (50/56) was significantly higher than the conventional therapy group 78.6% (44/56), the difference was statistically significant (P<0.05), but there was no significant difference between the two groups in HR, LVEDV, and LVEF. Conclusion Low-dose aspirin combined with metoprolol can improve the high blood coagulation and cardiac function of elderly patients with heart failure.
关键词
阿司匹林/联合/美托洛尔/老年心衰患者/血液高凝/心功能/改善作用Key words
aspirin/combined/metoprolol/elderly patients with heart failure/high blood coagulation/cardiac function/improvement role引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据