脑蛋白水解物在儿科临床中的应用
Application of cerebrolysin in pediatric clinic
赵明倩 1麦泳瑶 2刘毅 3邓湘俊 4陈琳 5程国华 6王霆1
作者信息
- 1. 广州一品红制药有限公司,广东 广州 510760;广东省生化制剂工程中心,广东 广州 510760
- 2. 广州一品红制药有限公司,广东 广州 510760;暨南大学 药学院,广东 广州 510632
- 3. 首都儿科研究所附属儿童医院 药学部,北京 100021
- 4. 中南大学湘雅 药学院,湖南 长沙410083
- 5. 暨南大学附属第一医院 药学部,广东 广州 510632
- 6. 暨南大学 药学院,广东 广州 510632
- 折叠
摘要
脑蛋白水解物是从猪脑组织中提取的具有器官特异性的氨基酸混合物水溶液,主要由85%游离状态氨基酸以及15%小分子肽组成.脑蛋白水解物能增加脑内氨基酸代谢及葡萄糖的转运,提高细胞抗缺氧能力,增强大脑对各类应激、损伤等恶性刺激的抵抗力;又能促进突触形成、诱导神经元分化,逆转脑损伤.脑蛋白水解物因其疗效和安全性在儿科临床中得到广泛应用,主要用于治疗新生儿缺氧缺血性脑病、小儿脑瘫、多动症、言语沟通障碍等儿童疾病.患儿经脑蛋白水解物治疗后临床症状得到不同程度改善,如意识恢复、理解记忆力增强、运动能力改善等.脑蛋白水解物治疗不仅能提高患儿痊愈率,还能减少后遗症的发生.本文对近年来国内外有关脑蛋白水解物在儿科临床应用及相关临床前研究作一综述,为临床医生应用脑蛋白水解物治疗儿科疾病提供更多依据.
Abstract
Cerebrolysin is an aqueous mixture of amino acids extracted from porcine brain, and mainly composed of 85% free amino acids and 15%small peptides. Cerebrolysin increase the metabolism of amino acids and glucose transport in the brain, improve the anti-anoxia ability of cells, and to enhance the brain's resistance to various types of malignant stimulation like stress and damage. Cerebrolysin can also promote synapse formation, induce neuronal differentiation, and help reverse brain injury. Because of its efficacy and safety, cerebrolysin has been widely used in the pediatric clinical practice, and primarily to treat neonatal hypoxic ischemic encephalopathy, childcerebral palsy, hyperactivity disorder, speech communication disorders, etc.The clinical symptoms were improved to some extent after the treatment of cerebrolysin. The recovery of consciousness, enhancement of comprehensionand memory, and improvement of the extremity motor function were observed. The treatment of cerebrolysincan not only enhance the cure rate, but also reduce the incidence of sequelae. This paper systematically summarized the clinical application of cerebrolysin in the pediatric population and relevant preclinical studies, to provide more guidance for clinical application of cerebrolysin in the treatment of pediatric diseases.
关键词
脑蛋白水解物/临床应用/新生儿缺氧缺血性脑病/小儿脑瘫/联合用药Key words
cerebrolysin/clinical application/hypoxic-ischemic encephalopathy/infantile cerebral palsy/drug combination引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据