首页|补肾方对预备再生育患者AMH及激素水平的影响

补肾方对预备再生育患者AMH及激素水平的影响

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目的 探讨补肾方对预备再生育患者抗苗勒管激素(anti-Mullerian hormone,AMH)及性激素水平的影响.方法 选取2014年6月~2016年6月杭州市中医院收治的卵巢储备功能低下不孕患者120例,随机分为对照组和研究组,分别为60例.对照组予以人工周期治疗,研究组予以补肾方加减治疗,2组均治疗3个月.观察比较治疗前后2组血清性激素及AMH含量,行阴道超声检测,同时对比临床疗效,随访1年统计妊娠率状况.结果 与治疗前比较,2组治疗后卵泡刺激素(Follicle stimulating hormone,FSH)、黄体生成素(Corpus lutein,LH)、雌二醇(Estradiol,E2)、FSH/LH含量降低,AMH含量升高,子宫内膜厚度、卵巢窦卵泡数量升高,中医症候积分降低(P<0.05);与对照组比较,研究组治疗后FSH、LH、FSH/LH、E2含量较低,AMH含量较高,子宫内膜厚度、卵巢窦卵泡数量较高,中医症候积分较低(P<0.05);研究组总有效率90.00%高于对照组总有效率73.33%(P<0.05);2组间不良反应率比较差异无统计学意义;研究组随访期间妊娠率30.00%高于对照组妊娠率11.67%(P<0.05).结论 补肾方对卵巢储备功能低下不孕患者疗效显著,能降低性激素及提高AMH含量,提高妊娠率.
Effect of Kidney nourishing decoction in the treatment of reproduce patients in serum hormone
Objective To investigate the effects of Kidney nourishing decoction in the treatment of reproduce patients in serum hormone .Methods 120 cases with reproduce patients from June 2014 to June 2016 in hangzhou traditional chinese medical hospital were selected,and divided into control group and experiment group, 60 cases in each group.The control group was given artificial cycle treatment, the experiment group was treated with Kidney nourishing decoction, two groups were treated for three months.Serum sex hormone and AMH content, clinical effect and pregnancy rate were compared before and after treatment.Results Compared with before treatment, levels of FSH, LH, E2 and FSH/LH in two groups decreased, AMH content increased after treatment,the thickness of endometrium and ovarian antral follicle number increased,symptom scores decreased after treatment (P <0.05);Compared with the control group, levels of FSH, LH, E2 and FSH/LH in the experiment group were lower, AMH content were higher, the thickness of endometrium and ovarian antral follicle number in the experiment group were higher,and the symptom scores were lower (P<0.05).The total effective rate of the study group was 90.00% higher than the total effective rate of the control group 73.33% (P<0.05).There was no significant difference in adverse reaction rate between the two groups, the pregnancy rate in the experiment group 30.00% was higher than the control group 11.67% ( P <0.05 ) .Conclusion Kidney nourishing decoction can reduce the sex hormone and increase the content of AMH , and increase the pregnancy rate in the treatment of reproduce patients.

Kidney nourishing decoctionovarian reserve functionanti -vaccine hormonesex hormone

邵梅、傅萍

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杭州市中医院 妇产科,浙江 杭州 310007

补肾方 卵巢储备功能低下 抗苗勒管激素 性激素

2016年浙江省中医药科技计划基金2014年国家中医药管理局全国名老中医药专家传承工作室建设项目

2016ZA147国中医药人教发201420号

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(2)
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