目的 探讨血府逐瘀汤联合脑蛋白水解物注射液对颅脑损伤的治疗效果及对脑脊液内皮素-1(endothelin-1,ET-1)的影响.方法 选择102例颅脑损伤患者,参照抽签法分为对照组(n=51)与实验组(n=51),对照组予以脑蛋白水解物注射液治疗,实验组基于对照组加用血府逐瘀汤治疗,比较2组疗效,ET-1、炎性因子、蛋白、血液流变学、S-100β、神经元特异性烯醇化酶(neuron specific enolase,NSE)、神经功能缺失评分(National Institutes of Health Stroke Scale,NIHSS)及并发症.结果 实验组总有效率(94.11%)高于对照组(78.43%),差异比较有统计学意义(P<0.05).实验组ET-1低于对照组[(32.45±4.05)ng/L vs.(28.11±3.50)ng/L](P<0.05).实验组炎性因子、蛋白、血液流变学、S-100β、NSE优于对照组(P<0.05).实验组NIHSS低于对照组(P<0.05).2组并发症率比较差异无统计学意义.结论 血府逐瘀汤联合脑蛋白水解物注射液对轮脑损伤的疗效确切,可降低脑脊液ET-1水平,并可促进炎性因子、蛋白及血液流变学等改善.
Therapeutic effect of Xiefu Zhuyu decoction joint brain protein hydrolysate injection in traumatic brain injury and its effect on cerebrospinal fluid of ET-1
Objective To explore the therapeutic effect of Xiefu Zhuyu decoction joint brain protein hydrolysate injection in the treatment of patients with traumatic brain injury and its effect on cerebrospinal fluid of endothelin-1 ( ET-1 ) .Methods 102 cases of patients with craniocerebral injury were divided into control group (n=51) and experimental group (n=51),the control group were treated with brain protein hydrolyzate injection, the experimental group based on the control group were treated with Xuefu Zhuyu decoction, the curative effect, ET-1, inflammatory factor, protein, blood rheology, S-100β, neuron specific enolase (NSE), National Institutes of Health Stroke Scale (NIHSS) and complications of two groups were compared.Results The total effective rate of experimental group was higher than the control group (94.11% vs.78.43%), the difference was statistically significant (P<0.05).The ET-1 of experimental group was lower than the control group[(32.45 ±4.05) ng/L vs.(28.11 ±3.50) ng/L] (P<0.05).The inflammatory factor, protein, blood rheology, NSE, S-100βof experimental group were better than those of control group (P<0.05). The NIHSS of experimental group was lower than that of the control group ( P <0.05 ) .The complication rate had no difference between two groups. Conclusion The clinical curative effect of Xiefu Zhuyu decoction joint brain protein hydrolysate injection in the treatment of traumatic brain injury , can reduce cerebrospinal fluid levels of ET-1 and can improve inflammatory factors, proteins and hemorheology.
craniocerebral injuryXiefu Zhuyu decoctionbrain protein hydrolysatecurative effectendothelin-1
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维普
