目的 探讨雷公藤多苷联合异维A酸胶囊治疗囊肿型痤疮患者疗效及对血清炎症因子、胰岛素样生长因子1(insulin like growth factor 1,IGF-1)和脱氢表雄酮(dehydroepiandrosterone,DHEA)的影响.方法 选取囊肿型痤疮患者118例按照随机数字表法分为观察组与对照组.对照组患者采用异维A酸胶囊治疗,观察组在对照组基础上结合雷公藤多苷片治疗.2组疗程均为8周.结果 观察组患者治疗总有效率(89.83%)高于对照组(71.19%)(P<0.05);观察组患者治疗后囊肿数目少于对照组(P<0.05);观察组患者治疗后血清IL-2和IL-4水平下降且低于对照组(P<0.05);观察组患者治疗后血清IGF-1和DHEA水平下降且低于对照组(P<0.05);观察组复发率(11.86%)低于对照组(30.51%)(P<0.05);2组不良反应发生率比较无统计学意义.结论 雷公藤多苷片联合异维A酸胶囊治疗囊肿型痤疮患者疗效明显,且可降低血清炎症因子IL-2和IL-4水平及降低IGF-1和DHEA水平,复发率低,不良反应少.
Therapeutic effect of tripterysium glycosides combined with isotretinoin in cysticacne and its effect on related indicators
Objective To investigate the effect of tripterysium glycosides combined with isotretinoin in cysticacne and its effect on serum inflammatory factors, insulin like growth factor 1 (IGF-1) and dehydroepiandrosterone (DHEA).Methods 118 cases of cysticacne patients were divided into observation group (n=59) and control group (n=59) according to the random number table method.Patients in the control group were treated with isotretinoin capsule, while the observation group were treated with tripterysium glycosides tablets on the basis of the control group.The course of treatment was 8 weeks in two groups.Results The total efficiency of the observation group (89.83%) was higher than the control group (71.19%) (P<0.05); the number of cyst after treatment in the observation group were less than the control group (P<0.05);the serum IL-2 and IL-4 levels in the observation group after treatment reduced, and lower than the control group (P<0.05);the serum IGF-1 and DHEA levels in the observation group after treatment reduced, and lower than the control group (P <0.05); the recurrence rate of the observation group (11.86%) was lower than the control group (30.51%) (P<0.05);the adverse reactions in two groups had no statistically significant.Conclusion Tripterysium glycosides combined with isotretinoin capsule has obvious curative effect in the treatment of cysticacne patients, and can reduce the serum IL-2, IL-4 levels and IGF-1 and DHEA levels, with lower recurrence rate, fewer adverse reactions.
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