四逆散加减联合雷贝拉唑肠溶胶囊治疗胃食管返流性咳嗽患者的效果及对IL-8、SP、MCT水平的影响
Clinical efficacy of Sini decoction adjustment combined rabeprazole enteric capsules in gastroesophageal reflux cough and its effect on IL-8, SP, MCT levels
王怡 1沈健 1魏夫荣1
作者信息
- 1. 海宁市中心医院 消化内科,浙江 海宁 314408
- 折叠
摘要
目的 探讨四逆散加减联合雷贝拉唑肠溶胶囊治疗胃食管返流性咳嗽的效果及对患者白细胞介素-8(interleukin 8,IL-8)、P物质(substance P,SP)和肥大细胞类胰蛋白酶(mast cell tryptase,MCT)水平的影响.方法 92例胃食管返流性咳嗽患者按照抽签法分为对照组与实验组,每组各46例.对照组采用雷贝拉唑肠溶胶囊治疗,实验组在对照组基础上加用四逆散加减治疗,比较2组疗效,咳嗽症状积分,IL-8、SP、MCT,胃动素(gastric dynamic element,MOT)及胃泌素(gastrin-releasing,GAS),肺功能和安全性.结果实验组总有效率(93.47%)高于对照组(76.08%),比较差异有统计学意义(P<0.05).治疗后,实验组咳嗽症状积分(1.53±0.19)分高于对照组(1.96±0.24)分,比较差异有统计学意义(P<0.05).实验组IL-8、SP、MCT水平均明显低于对照组(P<0.05).实验组MOT、GAS、肺功能较对照组改善更明显(P<0.05).2组安全性比较差异无统计学意义.结论 四逆散加减联合雷贝拉唑肠溶胶囊治疗胃食管返流咳嗽的效果确切,可降低患者IL-8、SP、MCT水平.
Abstract
Objective To research the clinical efficacy of Sini decoction adjustment combined rabeprazole enteric capsules in treatment of gastroesophageal reflux cough and its effect on interleukin 8 (IL-8) and substance P (SP), the mast cell tryptase (MCT) levels.Methods 92 cases of gastroesophageal reflux cough were divided into control group and experimental group by drawing method , each had 46 cases.Control group were treated by rabeprazole enteric capsules, experimental group were treated with rabeprazole enteric capsules based on the control group.The curative effect, cough symptoms integral, IL-8, SP, MCT, gastric dynamic element (MOT) and the gastrin-releasing (GAS), pulmonary function and safety were compared between two groups.Results The total effective rate of experimental group(93.47%) was higher than the control group(76.08%), the difference was statistically significant (P<0.05).After treatment, the symptoms of experimental group(1.53 ±0.19) points was higher than the control groupthe difference was statistically significant(1.96 ±0.24)points,P<0.05.The IL-8, SP, MCT levels of experimental group were all lower than the control group ( P<0.05 ) .The MOT, GAS, and lung function of experimental group improved more significantly than the control group ( P <0.05 ) .The security between two groups has no significant difference .Conclusion The curative effect of Sini decoction adjustment combined Rabeprazole enteric capsules in treatment gastroesophageal reflux cough is obvious, can decrease IL-8, SP, MCT levels.
关键词
胃食管反流性咳嗽/四逆散加减/雷贝拉唑肠溶胶囊/白细胞介素-8/P物质/肥大细胞类胰蛋白酶Key words
gastroesophageal reflux cough/Sini decoction adjustment/rabeprazole enteric capsules/interleukin-8/substance P/mast cell tryptase引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据