重组人促红素β注射液对糖尿病腹膜透析患者SOD、GSH-PX、MDA及Hcy水平的影响
Effects of recombinant human erythropoietin β injection on levels of SOD, GSH-PX, MDA and Hcy with diabetic peritoneal dialysis
陈竹青 1张荣国1
作者信息
摘要
目的 探讨重组人促红素β注射液对糖尿病腹膜透析患者超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、丙二醛(MAD)及高同型半胱氨酸(Hcy)水平的影响.方法 选择2014年9月~2016年9月宁波大学医学院接诊的92例糖尿病肾病终末期并行腹膜透析的患者,通过随机数字表法分为观察组和对照组,每组各46例.对照组给予腹膜透析常规治疗,观察组在此基础上,给予重组人促红素β注射液.比较2组血红蛋白(Hb)、红细胞压积(Hct)、肾功能、SOD、GSH-PX、MDA及Hcy水平的变化.结果 治疗后,观察组Hb、Hct水平比对照组高,差异有统计学意义(P<0.05);观察组尿蛋白排泄率(UAER)、血肌酐(SCr)水平均比对照组低,差异有统计学意义(P<0.05);观察组SOD、GSH-PX水平高于对照组,MDA、Hcy水平比对照组低,差异有统计学意义(P<0.05).结论 在糖尿病肾病腹膜透析患者中应用重组人促红素β注射液效果显著,可有效改善SOD、GSH-PX、MDA及Hcy水平.
Abstract
Objective To investigate the effects of recombinant human erythropoietin βinjection on levels of superoxide dismutase ( SOD ) , glutathione peroxidase ( GSH-PX ) , malondialdehyde ( MDA ) and homocysteine ( Hcy ) in patients with diabetic peritoneal dialysis.Methods 92 patients of parallel peritoneal dialysis in diabetic nephropathy who received therapy from September 2014 to September 2016 in our hospital were selected and randomly divided into the observation group and the control group with 46 cases in each group.The control group was treated with peritoneal dialysis routine treatment, while the observation group was treated with recombinant human erythropoietin βinjection on this basis.The levels of hemoglobin (Hb), hematocrit (Hct), renal function, SOD, GSH-PX, MDA and Hcy were compared.Results After treatment, the levels of Hb and Hct in the observation group were higher than the control group, the difference was statistically significant (P<0.05), the urinary albumin excretion rate (UAER) and serum creatinine (SCr) in the observation group were lower than the control group, the difference was statistically significant (P<0.05), the levels of SOD and GSH-PX in the observation group were higher than the control group, the levels of MDA and Hcy were lower the control group, the difference was statistically significant (P<0.05).Conclusion The effect of recombinant human erythropoietin βinjection on diabetic nephropathy patients with peritoneal dialysis was significant, which could improve the levels of SOD, GSH-PX, MDA and Hcy.
关键词
糖尿病肾病/腹膜透析/重组人促红素β注射液/氧化应激/高同型半胱氨酸Key words
diabetic nephropathy/peritoneal dialysis/recombinant human erythropoietin βinjection/oxidative stress/homocysteine引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据