目的 分析抗甲状腺药物(anti-thyroid drugs,ATD)治疗原发性甲状腺功能亢进症(primary hyperthyroidism,PHT)的临床有效性与超声学变化.方法 选取83例浙江省诸暨市人民医院超声科于2013年2月~2015年8月接诊的PHT患者,根据超声检测的结果对其进行分组,分为回声不均匀组41例,回声均匀组42例.对2组患者进行ATD治疗(予以他巴唑治疗),比较2组甲状腺相关指标与甲状腺右上叶动脉的血流动力学指标,统计2组疗效情况.结果 治疗后,回声均匀组血管阻力指数(systemic vascular resistance index,RI)为(0.62±0.17),回声不均匀组为(0.65±0.18),2组无明显差异;回声均匀组甲状腺右叶上动脉管直径(thyroid artery diameter on the right lobe,D)、收缩期峰值流速(the peak systolic velocity,Vmax)、舒张期最小血流速度(minimum diastolic blood flow velocity,Vmin)、甲状腺体积(thyroid volume,V)、血流量(blood flow volume,Q)均显著低于回声不均匀组,差异有统计学意义(P<0.05);回声不均匀组总有效率(48.78%)显著低于回声均匀组(85.71%),差异有统计学意义(P<0.05).结论 ATD用于治疗PHT取得了较好疗效,可大幅改善患者甲状腺血流动力学指标,对调节患者甲状腺相关指标水平有积极意义,临床治疗有效率较高,尤其是治疗彩超回声均匀的患者效果更佳.
Clinical efficacy and ultrasonographic evaluation of anti-thyroid drugs in the treatment of primary hyperthyroidism
Objective To investigate the clinical efficacy and ultrasonographic changes treated with anti-thyroid drugs ( ATD ) in patients with primary hyperthyroidism(PHT).Methods 83 cases of PHT patients admitted to the department of ultrasound from February 2013 to August 2015 in Zhuji People's Hospital of Zhejiang Province were selected, the patients were divided into two groups according to the results of ultrasonography, echo nonuniform group 41 cases and echo uniform group 42 cases.ATD therapy was administered to the both groups (were treated with methimazole).The thyroid related indexes and hemodynamics of thyroid right superior diagnosed by color doppler ultrasound, and the curative efficacies of the two groups were analyzed.Results After treatment, the systemic vascular resistance index(RI) of echo uniform group was (0.62 ±0.17), and the echo nonuniform group was (0.65 ±0.18), there was no significant difference between the two groups.The echo uniform group of thyroid artery diameter on the right lobe(D), the peak systolic velocity(Vmax), minimum diastolic blood flow velocity(Vmin), thyroid volume(V) and blood flow volume(Q) were significantly lower than the echo nonuniform group, the difference was statistically significant (P <0.05).The total effective rate of the echo nonuniform group (48.78%) was significantly lower than that in the echo uniform group (85.71%), the difference was statistically significant(P <0.05).Conclusion ATD has a good effect in treating PHT, and can significantly improve the thyroid hemodynamics in patients, it has a positive effect on the regulation of thyroid-related parameters in patients, the clinical treatment is effective, and the effect is better especially in patients with uniform echo.
NETL
NSTL
万方数据
维普
