首页|艾司西酞普兰治疗急性期精神分裂症伴抑郁患者的效果及对疾病相关血液指标的影响

艾司西酞普兰治疗急性期精神分裂症伴抑郁患者的效果及对疾病相关血液指标的影响

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目的 分析艾司西酞普兰治疗急性期精神分裂症伴抑郁患者的效果及对疾病相关血液指标的影响.方法 选取2015年2月~2016年8月期间于浙江省长广(集团)有限责任公司职工医院收治的84例急性期精神分裂症伴抑郁患者为研究对象,将其随机分为对照组(常规治疗组)42例和观察组(常规治疗加艾司西酞普兰组)42例,然后将2组患者治疗后不同时间的临床总有效率、治疗前后的血浆游离氨基酸及应激指标进行比较.结果 观察组治疗后不同时间的临床总有效率均高于对照组,差异有统计学意义(P<0.05),治疗后的血浆游离氨基酸均高于对照组,差异有统计学意义(P<0.05),血清应激指标均低于对照组,差异有统计学意义(P<0.05).结论 艾司西酞普兰在急性期精神分裂症伴抑郁患者中的应用效果较好,且其对患者的疾病相关血液指标有积极的改善作用.
Efficacy of escitalopram in acute schizophrenia and depression and its influence on blood parameters with disease
Objective To analyze the application effect of escitalopram in the patients with acute schizophrenia with depression and influence situation for the disease related blood indexes.Methods 84 patients with acute schizophrenia with depression in our hospital from February 2015 to August 2016 were selected as the study object, and they were randomly divided into control group(conventional treatment group)42 cases and observation group( conventional treatment and escitalopram group ) 42 cases, then the total effective rates, plasma free amino acids and stress hormones indexes before and after the treatment of two groups were compared.Results The total effective rates of observation group at different time after the treatment were all higher than those of control group, the difference was statistically significant (P<0.05), the plasma free amino acids after the treatment were all higher than those of control group, the difference was statistically significant (P<0.05), serum stress hormones were all lower than those of control group, the difference was statistically significant (P<0.05), the differences of two groups were all significant.Conclusion The application effect of escitalopram in the patients with acute schizophrenia with depression is better, and it also has active improvement role for the disease related blood indexes of patients.

escitalopramacute schizophreniadepressionapplication effectdisease related blood indexes

张群、王小军、杜姝雯

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浙江省长广(集团)有限责任公司职工医院药剂科,浙江 湖州 313117

浙江省长广(集团)有限责任公司职工医院精神科,浙江 湖州 313117

浙江省长广(集团)有限责任公司职工医院 院感科,浙江 湖州 313117

艾司西酞普兰 急性期精神分裂症 抑郁 应用效果 疾病相关血液指标

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(2)
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