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不同剂量咪达唑仑对肺癌手术患者的麻醉效果及安全性

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目的 观察不同剂量咪达唑仑对肺癌手术患者的麻醉效果及安全性,探索合适的剂量.方法 选择宁波市鄞州区第二医院2014年6月~2016年1月进行肺癌根治术的患者60例,根据咪达唑仑的用量不同分为观察组和对照组,每组30例,观察2组血流动力学变化、苏醒时间、拔管时间、疼痛评分及麻醉药物用量.结果 2组血流动力学指标在各个时间点比较,差异均无统计学意义;观察组苏醒时间、拔管时间、疼痛评分、丙泊酚用量及瑞芬太尼用量均明显低于对照组,差异有统计学意义(P<0.05).结论 选择0.075 mg/kg的咪达唑仑用于肺癌手术麻醉前诱导可减轻手术带给患者的刺激,使手术顺利进行.
Anesthetic effect and safety of different doses of midazolam on lung cancer
Objective To observe the anesthesia effect and safety of different doses of midazolam on operation in patients with lung cancer , to explore the appropriate dose.Methods 60 cases with lung cancer were divided into observation group and control group according to the dosage of midazolam,30 cases in each group.Hemodynamic changes, recovery time, extubation time, pain score and the dosage of anesthetic drug in the two groups were observed.Results There was no significant differences in hemodynamic indexes of each time point of the two groups .Compared with control group, recovery time, extubation time, pain score, the dosage of propofol and remifentanil dosage in the observation group were significantly lower than that of the control group, the difference was statistically significant (P <0.05).Conclusion Select the 0.075 mg/kg midazolam for lung cancer operation before anesthesia induction can reduce the operation to patients stimulation, make the operation smoothly.

different dosemidazolamlung canceranesthesiaeffect

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宁波市鄞州区第二医院 药剂科,浙江 宁波 315100

不同剂量 咪达唑仑 肺癌 麻醉 效果

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(2)
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