丙酸氟替卡松联合无创正压通气治疗COPD的临床疗效及对患者肺功能的影响
Clinical efficacy of fluticasone propionate combined with noninvasive positive pressure ventilation on COPD and its effect on pulmonary function
傅婷霞 1郑宏兴 1张建江1
作者信息
- 1. 诸暨市第四人民医院 内科,浙江 诸暨 311835
- 折叠
摘要
目的 探究丙酸氟替卡松联合无创正压通气治疗慢性阻塞性肺疾病(COPD)患者的临床效果.方法 选择2014年10月~2016年10月诸暨市第四人民医院急诊科收治的88例COPD患者,随机分为对照组和观察组2组,每组各44例.对照组经常规治疗,观察组经丙酸氟替卡松的联合无创正压通气治疗,再对比2组疗效.结果 观察组治疗总有效率为100.0%显著高于对照组70.5%,差异有统计学意义(P<0.05);治疗后观察组用力肺活量(FVC)为(2.50±0.32)L,第一秒用力呼气容积(FEV1)为(1.36±0.20)L,第一秒用力呼气容积占预计值比例(FEV1%)为(51.23±4.32),动脉血氧分压(PaO2)为(10.51±2.10)kPa,动脉血二氧化碳分压(PaCO2)为(5.15±1.19)kPa,与对照组对比,差异有统计学意义(P<0.05);观察组复发率为4.5%显著低于对照组13.6%,差异有统计学意义(P<0.05).结论 COPD患者采用丙酸氟替卡松的联合无创正压通气治疗,能够有效改善肺功能,降低疾病复发率,疗效显著.
Abstract
Objective To investigate the clinical effect of fluticasone propionate combined with noninvasive positive pressure ventilation in the treatment of chronic obstructive pulmonary disease (COPD).Methods 88 cases of COPD patients from October 2014 to October 2016 in our hospital were selected and randomly divided into two groups of the control group observation group with 44 cases in each group.The control group was treated with conventional treatment, the observation group was treated with fluticasone propionate plus noninvasive positive pressure ventilation, and then the curative effect of the two groups was compared.Results The total effective rate of observation group was 100% higher than that of the control group 70.5%, the difference was statistically significant (P<0.05), after treatment, the observation group of FVC (2.50 +0.32) L, FEV1 (1.36 +0.20) L, FEV1%(51.23+4.32), PaO2(10.51+2.10) kPa, PaCO2(5.15 +1.19) kPa, compared with the control group, the difference was statistically significant (P<0.05), the observation group recurrence rate 4.5% was lower than the control group 13.6%, the difference was statistically significant (P <0.05).Conclusion COPD patients with fluticasone propionate combined noninvasive positive pressure ventilation, can effectively improve lung function, reduce disease recurrence rate, a significant effect.
关键词
丙酸氟替卡松/无创正压通气/联合/COPD/疾病复发率Key words
fluticasone propionate/noninvasive positive pressure ventilation/combine/COPD/disease recurrence rate引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据