首页|肝硬化患者血浆BNP水平与血清白蛋白、血清总胆红素及凝血酶原时间相关性研究

肝硬化患者血浆BNP水平与血清白蛋白、血清总胆红素及凝血酶原时间相关性研究

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目的 探讨肝硬化患者血浆脑利钠肽(brain natriuretic peptide,BNP)水平与血清白蛋白、血清总胆红素及凝血酶元时间的相关性.方法 随机选取2014年1月~2016年6月到余姚市第二人民医院诊断并住院治疗的肝硬化患者200例,根据2006年中华医学肝病学分会提供的肝功能Child-Pugh分级标准分组:Child A级组48例、Child B级组96例和Child C级组56例.通过分析各组患者临床资料及对比患者实验室检测的血浆BNP、血清白蛋白、血清总胆红素、凝血酶原时间和心电图QTc间期等,探讨血浆BNP与各指标的相关性.结果 对比Child A、B、C级3组的血浆BNP水平,A组大于B组,B组大于C组,相关检测表明血浆BNP与Child分级呈正相关,各组两两比较的结果具有统计学差异(P<0.05);分析血浆BNP水平与ALB的相关性,ALB越高,血浆BNP越低,相关回归分析表明血浆BNP与ALB呈负相关,差异具有统计学意义(P<0.05);分析血浆BNP水平与TBIL的相关性,TBIL越高,血浆BNP越高,相关回归分析表明血浆BNP与TBIL呈正相关,差异具有统计学意义(P<0.05);分析血浆BNP水平与PT的相关性,PT越长,血浆BNP越高,相关回归分析表明血浆BNP与TBIL呈正相关,差异具有统计学意义(P<0.05).分析血浆BNP水平与QTc的相关性,血浆BNP水平高的组QTc间期较长,差异具有统计学意义(P<0.01).结论 肝功能患者血浆BNP水平与ALB、TBIL、PT、QTc间期关系密切,具有评价和预测肝功能状态的价值.
Plasma BNP levels and serum albumin, serum total bilirubin and prothrombin time in patients with cirrhosis correlation
Objective To investigate the correlation of plasma brain natriuretic peptide (BNP) level with serum albumin, serum total bilirubin and thrombin time in patients with liver cirrhosis.Methods RandomLy selected from January 2014 to June 2016 to our hospital diagnosis and hospitalization of 200 cases of cirrhosis patients, according to the standard of Child-Pugh classification provided by Chinese Medical Hepatology Division in 2006, 48 cases were Child A group, 96 cases were Child B group and 56 cases were Child C group.The plasma BNP, serum albumin, serum total bilirubin, prothrombin time and QTc interval of electrocardiogram were analyzed in the clinical data of each group of patients and the correlation between plasma BNP and their correlation.Results The levels of plasma BNP in Child A, B and C groups were higher than those in B group and B group.The correlation between plasma BNP and Child's grade showed a positive correlation, and the results of each group were statistically different (P<0.05).The plasma BNP level was negatively correlated with ALB ( P<0.05 ) .The level of plasma BNP was positively correlated with ALB ( P <0.05 ) .The correlation between plasma BNP and PTIL was correlated with TBIL.The correlation between plasma BNP and TBIL was significantly correlated with TBIL ( P <0.05), The higher the plasma BNP, the regression analysis showed that plasma BNP and TBIL were positively correlated, the difference was statistically significant (P<0.05).The correlation between plasma BNP level and QTc was analyzed.The QTc interval of plasma BNP level was higher than that of the control group ( P<0.01 ) , and the difference was statistically significant ( P <0.01 ) .Conclusion The plasma BNP level in patients with liver function is closely related to ALB, TBIL, PT, QTc interval, and has the value of evaluating and predicting liver function.

plasma BNP levelsserum albuminserum total bilirubinprothrombin time

沈群红、诸景辉、罗孟丽、周建波

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余姚市第二人民医院 内科,浙江 余姚 315400

余姚市人民医院 内科,浙江 余姚 315400

血浆BNP水平 血清白蛋白 血清总胆红素 凝血酶原时间

浙江省卫生适宜技术成果转化计划

2014ZHA008

2017

10.3969/j.issn.1005-1678.2017.02.090

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN：1005-1678
年,卷(期)：2017.37(2)
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