持续性心房颤动患者血脑钠肽水平改变与肾素血管紧张素醛固酮系统的关系
Relationship between plasma brain natriuretic peptide level and renin-angiotensin-aldosterone system in patients with persistent atrial fibrillation
朱峰 1黄振荣 1任萍 1何巍2
作者信息
- 1. 宁波大学医学院附属医院 急诊科,浙江 宁波 315000
- 2. 浙江大学医学院附属第二医院 心内科,浙江 杭州 310009
- 折叠
摘要
目的 探讨持续性心房颤动(persistent atrial fibrillation,PAF)患者血脑钠肽(brain natriuretic peptide,BNP)水平改变与肾素血管紧张素醛固酮系统(renin-angiolensin-aldosterone system,RAAS)的关系.方法 选取2013年12月~2015年10月宁波大学医学院附属医院经冠脉造影证实冠脉有大于50%狭窄的冠心病患者80例,按照随机实验原则分成PAF组(40例)和对照组(窦性心律,40例),检测2组患者BNP、肾素、血管紧张素Ⅱ、醛固酮水平,并进行左房内径(left atrial diameter,LAD)测量.结果 在心功能等级相同条件下,PAF组血BNP浓度高于对照组(P<0.05);直线回归进行相关关系分析结果表明:PAF组患者的血BNP水平与AngII浓度的相关系数r为0.301,PAF组患者的血BNP水平与LAD指标的相关系数r为0.373,BNP和RAAS的浓度与LVMI均呈正相关,差异具有统计学意义(P<0.05),PAF患者的血BNP水平与其RAAS浓度水平密切相关(P<0.05).结论 PAF患者的血BNP浓度明显升高,患者的血BNP水平和RAAS的浓度与LVMI均呈正相关.
Abstract
Objective Through clinical observation and research with persistent atrial fibrillation in patients with blood-brain natriuretic peptide ( BNP) level change detection renin, angiotensin Ⅱ, aldosterone, analyze their data, investigate persistent atrial fibrillation ( PAF ) serum brain natriuretic hormone levels change and the relationship between the renin-angiotensin-aldosterone system (RAAS).Methods 80 patients with coronary artery disease in our hospital from December 2013 to October 2015 were selected, randomly divided into experimental principle PAF group (40 cases) and control group ( patients in sinus rhythm,with 40 cases) , BNP, renin, angiotensinⅡ, aldosterone levels were measured in two groups, and left atrial diameter (LAD) measurements.Results Under the same condition of cardiac function, the blood BNP concentration in PAF group was higher than that in control group (P <0.05).The results of the linear regression analysis showed that the correlation coefficient of blood BNP level and AngII concentration in PAF group was 0.301, the correlation coefficient of blood BNP level and LAD indicators in PAF group was 0.373, the concentrations of BNP and RAAS were positively correlated with LVMI, the differences were statistically significant (P<0.05), the blood BNP level was closely related to the level of RAAS in the PAF group (P<0.05).Conclusion Blood BNP concentration was significantly higher in patients with PAF and blood BNP concentration is closely related with the RAAS, LAD indicators, and a positive correlation.
关键词
持续性心房颤动/血脑钠素/肾素/血管紧张素Ⅱ/醛固酮Key words
persistent atrial fibrillation/blood-brain natriuretic peptide/renin/angiotensin Ⅱ/aldosterone引用本文复制引用
基金项目
浙江省医药卫生科技计项目(2014RCA008)
出版年
2017
NETL
NSTL
维普
万方数据