腹腔镜手术与开腹手术对重症急性胰腺炎患者外周血T淋巴细胞亚群及Th1Th2的影响比较
Comparison of effects of laparoscopic operation and open operation for the peripheral blood T lymphocyte subsets and Th1 Th2 of patients with severe acute pancreatitis
沈海幸 1万亚锋 2杨祺俊2
作者信息
- 1. 慈溪市人民医院 普外科,浙江 慈溪 315300
- 2. 杭州市第一人民医院 肝胆胰外科,浙江 杭州 310006
- 折叠
摘要
目的 比较腹腔镜手术与开腹手术对重症急性胰腺炎患者外周血T淋巴细胞亚群及Th1Th2的影响程度.方法 选取2013年2月~2014年12月于慈溪市人民医院和杭州市第一人民医院进行手术治疗的54例患者为研究对象,开腹手术治疗的27例重症急性胰腺炎患者为A组,同时期采用腹腔镜手术治疗的27例患者为B组,将2组患者术前及术后1、3、7 d的外周T淋巴细胞亚群及血清Th1Th2指标进行分别检测,将2组患者的检测结果进行比较.结果 B组患者术后1、3、7 d的外周血T淋巴细胞亚群及血清Th1Th2指标均显著地好于A组,差异有统计学意义(P<0.05),且A组与B组患者术后3d的检测结果差于其他时间,差异有统计学意义(P<0.05).结论 腹腔镜手术与开腹手术对重症急性胰腺炎外周血T淋巴细胞亚群及Th1Th2的影响存在较大差异,腹腔镜手术对患者上述指标的不良影响相对更小.
Abstract
Objective To compare the influence degree of laparoscopic operation and open operation on peripheral blood T lymphocyte subsets and Th1Th2 in patients with severe acute pancreatitis.Methods 54 patients who underwent surgical treatment in our hospital from February 2013 to December 2014 were selected as the subjects, 27 patients with severe acute pancreatitis who were treated with open operation as group A , 27 cases who were treated with laparoscopic operation at the same time were selected as group B , and then the peripheral blood T lymphocyte subsets and serum Th1Th2 indexes of two groups before the operation and at first,third and seventh day after the operation were respectively detected, then the detection results of two groups were compared.Results The peripheral blood T lymphocyte subsets and serum Th1Th2 indexes of group B at first, third and seventh day after the operation were all significantly better than those of group A , the difference was statistically significant ( P<0.05 ) , and the detection results of group A and group B at third day after the operation were worse than those at other time , the difference was statistically significant (P<0.05).Conclusion The influence of laparoscopic operation and open operation on T lymphocyte subsets and Th1Th2 in peripheral blood of patients with severe acute pancreatitis, the adverse effects of laparoscopic operation on the above indicators were relatively small.
关键词
腹腔镜手术/开腹手术/重症急性胰腺炎/外周血T淋巴细胞亚群/Th1Th2Key words
laparoscopic operation/open operation/severe acute pancreatitis/peripheral blood T lymphocyte subsets/Th1Th2引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据