首页|青蒿素及其衍生物的抗肿瘤研究进展

青蒿素及其衍生物的抗肿瘤研究进展

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青蒿素及其衍生物的抗肿瘤作用已成为近年来研究热点.青蒿素及其衍生物主要通过阻滞肿瘤细胞周期、促进肿瘤细胞凋亡、抑制肿瘤血管生成等发挥抗肿瘤作用,其对有关信号通路的影响已经引起学者们的广泛研究兴趣.目前已有许多研究者致力于新型青蒿素衍生物的合成与开发,以期发现具有更好疗效的化合物.此外,青蒿素及其衍生物逆转肿瘤耐药性的研究也成为重要发展趋势之一.本文对最近5年来青蒿素及其衍生物的抗肿瘤研究进行了述评和展望.
Study progress on antitumor activities of artemisinin and its derivatives
The antitumor activities of artemisinin and its derivatives has become a hot topic in recent years.Artemisinin and its derivatives have been reported to exert antitumor effects mainly by blocking the cell cycle, promoting tumor cell apoptosis, inhibiting angiogenesis and so on.Also, their influence on signaling pathways has attracted considerable interest of many scholars.Currently, in order to discover some compounds with better therapeutic potentials, many studies dedicated to the synthesis and development of new artemisinin derivatives.In addition, the effects of artemisinin and its derivatives on multi-drug resistantace in tumor cells also become a trend of the future research.In this paper, we review the research advances in the antitumor activities of artemisinin and its derivatives during the past five years to provide a reference for future study .

artemisininderivativesantitumorstudy progress

李晶晶、陈飞飞、宋丽艳、朱建华、于荣敏

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暨南大学药学院,广东广州510632

暨南大学中药生物技术研究所,广东广州510632

中国人民解放军第93279部队医院,辽宁丹东118008

青蒿素 青蒿素衍生物 抗肿瘤 研究进展

国家自然科学基金国家自然科学基金广东省自然科学基金

81073004811027712014A030313385

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(3)
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