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丹参饮片品质评价与方法

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目的 对市售6种丹参饮片药材进行综合质量评价,并比较丹参评价方法.方法 参照中国药典2015版一部丹参项下的鉴别、检查、定量检测方法,丹参HPLC色谱指纹图谱分析方法对市售丹参饮片药材进行综合质量评价.结果 6种样品丹参酮IIA定量结果均不符合规定、50%样品丹参酚酸B不符合规定、色谱指纹图谱无论是脂溶性成分与水溶性成分均显示与标准药材存在差异.结论 丹参饮片药材质量应引起关注,加强药材市场监管的力度;HPLC色谱指纹图谱法对丹参评价客观,实用.
Quality evaluation of radix salvia miltiorrhizae tablets and the methods thereof
Objective To evaluate the quality of six kinds of radix salvia miltiorrhizae tables and verify the methods of the quality evaluation . Methods Identification, detection and quantitative test method in Chinese Pharmacopoeia Part One 2005 edition and the HPLC-FPC analysis method were used to evaluate the quality of six kinds of radix salvia miltiorrhiza tables.Results The content of tanshinone IIA of six samples is not in accordance with that in the Chinese Pharmacopoeia and the content of lithospermate B of three samples is not in accordance with that in the Chinese Pharmacopoeia.Both the content of lip-soluble component and the water-soluble component of all the samples differ from those of standard radix salvia miltiorrhiza tables.Conclusion The HPLC-FPC analysis method is useful and effective to identify and detect the quality of the HPLC-FPC analysis method.More attention shall be paid to the quality of the radix salvia miltiorrhiza tables and the supervision of the radix salvia miltiorrhizae tables market should be strengthened.

radix salvia miltiorrhizae tabletsquality evaluationHPLC

李峧霓、丁盛、何昌国

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浙江省临海市中医院药剂科,浙江临海317000

杭州胡庆余堂药业有限公司技术品质部,浙江杭州310026

丹参饮片 品质评价 高效液相色谱

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(3)
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