苦碟子注射液用于急性脑梗死的临床评价及对患者血清VEGF、S-100β、MMP-9水平的影响
Clinical evaluation of Kudiezi injection in acute cerebral infarction and its effects on serum VEGF, S-100βand MMP-9 levels
李增攀 1周挺 1蒋黎1
作者信息
- 1. 宁波市医疗中心李惠利东部医院急诊科,浙江宁波315000
- 折叠
摘要
目的 探讨苦碟子注射液用于急性脑梗死的临床评价及对患者血清血管内皮生长因子(VEGF)、S-100β、基质金属蛋白酶(MMP)-9水平的影响.方法 选取2014年10月~2016年10月宁波市医疗中心李惠利东部医院接诊的98例急性脑梗死患者,通过随机数表法分为观察组和对照组,每组各49例.对照组给予常规治疗,观察组联合苦碟子注射液治疗.治疗14 d后,比较2组临床疗效、血清VEGF、S-100β、MMP-9、美国国立卫生研究院卒中量表(NIHSS)以及Barthel指数结果.结果 治疗后,观察组临床疗效总有效率87.75%(43/49)明显高于对照组65.31%(32/49),差异有统计学意义(P<0.05);观察组VEGF水平明显比对照组高,S-100β、MMP-9水平均明显低于对照组,差异有统计学意义(P<0.05);观察组NIHSS评分明显低于对照组,差异有统计学意义(P<0.05);观察组Barthel指数明显高于对照组,差异有统计学意义(P<0.05).结论 在急性脑梗死患者中应用苦碟子注射液效果显著,可有效改善血清VEGF、S-100β、MMP-9水平,促进神经功能恢复,提高生活质量.
Abstract
Objective To investigate clinical evaluation of Kudiezi injection in treatment of acute cerebral infarction and its effects on serum vascular endothelial growth factor(VEGF), S-100β, matrix metalloproteinases(MMP)-9 levels.Methods 98 patients of acute cerebral infarction who received therapy from October 2014 to October 2016 in our hospital were selected.Those patients were randomly divided into the observation group and the control group with 48 cases in each group.The control group was treated with routine treatment, while the observation group was treated with Kudiezi injection.After treatment of 14 days, the clinical curative effect, serum VEGF, S-100β, MMP-9, National institutes of health stroke scale (NIHSS) and Barthel index were compared.Results After treatment, the total effective rate in the observation group 87.75%(43/49) was significantly higher than that of the control group 65.31%( 32/49 ) , the difference was statistically significant ( P<0.05 ) , the level of VEGF in the observation group was significantly higher than that of the control group, and the S-100βand MMP-9 were significantly lower than that of the control group, the difference was statistically significant (P<0.05), the NIHSS score in the observation group was significantly lower than that of the control group, the difference was statistically significant (P<0.05), the Barthel index in the observation group was significantly higher than that of the control group, the difference was statistically significant (P<0.05).Conclusion Kudiezi injection is well for acute cerebral infarction, which can effectively improve the serum levels of VEGF, S-100β, MMP-9, and can improve the therapeutic effect, promote the recovery of neurological function and improve the quality of life.
关键词
急性脑梗死/苦碟子注射液/血管内皮生长因子/S-100β蛋白/基质金属蛋白酶-9Key words
acute cerebral infarction/Kudiezi injection/vascular endothelial growth factor/S-100βprotein/matrix metalloproteinases -9引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据