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仙灵骨葆胶囊联合鹿瓜多肽注射液对椎体骨质疏松的临床疗效

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目的 研究仙灵骨葆胶囊联合鹿瓜多肽注射液对椎体骨质疏松的临床疗效.方法 选取2014年3月~2015年3月东阳市人民医院接诊的90例椎体骨质疏松患者作为本次研究对象按随机数字表法分为观察组和对照组,每组各45例.对照组患者采用鹿瓜多肽治疗,观察组采用仙灵骨葆胶囊联合鹿瓜多肽治疗,观察2组患者治疗后骨密度、骨钙素,视觉模拟评分法(visual analogue scale,VAS)、Oswestry功能障碍指数(Oswestry disability index,ODI)评分治疗疗效.结果 治疗后,观察组骨密度、骨钙素均高于对照组[(0.99±0.13)g/cm2 vs(0.89±0.14)g/cm2、(41.05±5.30)μg/L vs(35.80±5.23)μg/L],差异有统计学意义(P<0.05);观察组VAS、ODI评分,小于对照组[(1.21±0.30)分vs(4.65±1.08)分、(18.24±4.97)%vs(31.26±5.73)%],差异有统计学意义(P<0.05);观察组总有效率优于对照组95.55%(43/45),差异有统计学意义vs77.77%(35/45)(P<0.05).结论 仙灵骨葆胶囊联合鹿瓜多肽注射液对椎体骨质疏松的疗效显著,能够改善患者的骨代谢,促进骨生长,提高治疗疗效.
Curative efficacy of Xianlinggubao capsules combined with Lugua polypeptide injection in vertebral osteoporosis
Objective To explore curative efficacy of Xianlinggubao capsules combined with Lugua polypeptide injection in treatment of vertebral osteoporosis.Methods 90 patients of vertebral osteoporosis from March 2014 to March 2015 in our haspital were selected as research objects and randomly divided into the observation group and control group,with 45 cases in each group.The control group were treated with Lugua polypeptide injection, while the observation group were treated with Xianlinggubao capsules combined with Lugua polypeptide injection.Then bone mineral density, osteocalcin, visual analogue scale (VAS), Oswestry disability index (ODI) score, curative effect in two groups after treatment were compared.Results Ater treatment, bone mineral density, osteocalcin in observation group was than that in control group [(0.99 ±0.13)g/cm2 vs(0.89 ±0.14)g/cm2, (41.05 ±5.30)μg/L vs(35.80 ±5.23)μg/L],the difference was statistically significant(P<0.05); VAS、ODI score in observation group were lower than those in control group[(1.21 ±0.30)分vs(4.65 ±1.08)分、(18.24 ±4.97)% vs(31.26 ±5.73)%],the difference was statistically significant (P<0.05).The total effective rate of observation group was statistically higher than that in the control group 95.55%(43/45),the difference was statistically significant vs77.77%( 35/45 ) ( P<0.05 ) .Conclusion Xianlinggubao capsules combined with Lugua polypeptide injection is well for vertebral osteoporosis,which can improve the bone metabolism of patients, promote bone growth and improve treatment efficacy.

Xianlinggubao capsulesLugua polypeptide injectionvertebral osteoporosisclinical effect

金永鑫、吕晓强、刘志英

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东阳市人民医院骨科,浙江东阳322100

仙灵骨葆胶囊 鹿瓜多肽注射液 椎体骨质疏松 临床疗效

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(3)
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