首页|抗心绞痛联合抗焦虑-抑郁药物在心绞痛合并焦虑抑郁患者中的临床效果及对心理波动的影响

抗心绞痛联合抗焦虑-抑郁药物在心绞痛合并焦虑抑郁患者中的临床效果及对心理波动的影响

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目的 分析抗心绞痛联合抗焦虑-抑郁药物在心绞痛合并焦虑抑郁患者中的临床效果及对心理波动的影响.方法 选取100例合并焦虑抑郁的冠心病心绞痛患者作为观察对象,按照数字表法随机分为观察组与对照组,每组各50例.对照组给予常规心绞痛治疗药物,观察组在对照组的基础上加入抗焦虑抑郁药物治疗.比较2组患者的心绞痛治疗效果及不良反应发生率,并比较2组患者治疗前后依从性、心功能指标包括左心室收缩末期容积(LVESV)、左室射血分数(LVEF)、左心室舒张末期容积(LVEDV)和焦虑抑郁评分变化.结果 观察组总治疗有效率明显高于对照组(P<0.05);2组患者均无严重不良反应发生;观察组治疗依从优良率显著优于对照组(P<0.05);2组患者治疗后各心功能指标明显优于治疗前(P<0.05),且观察组治疗后各心功能指标水平明显优于对照组(P<0.05);观察组治疗前后焦虑抑郁评分差异有统计学意义(P<0.05),而对照组治疗前后焦虑抑郁评分差异无统计学意义.结果抗心绞痛联合焦虑-抑郁药物在心绞痛合并焦虑抑郁患者中具有较好的临床疗效,能够有效控制心绞痛的发作,同时具有较高的安全性,能够提高患者对临床治疗的依从性,缓解其焦虑抑郁情绪,从而提高患者的生活质量.
Anti-angina pectoris combined with anxiolytic-depressive drugs in angina pectoris with anxiety and depression and its influence on psychological fluctuation
Objective To analyze the clinical effect of anti-angina pectoris combined with anxiolytic-depressive drugs in patients with angina pectoris and anxiety and depression and its influence on psychological fluctuation .Methods 100 patients with coronary heart disease and angina pectoris who were treated with anxiety and depression were randomly divided into the observation group and the control group according to the digital table method.The control group were treated with conventional angina pectoris, and the control group were treated with anti-anxiety and depression medication.The left ventricular end-systolic volume ( LVESV ) , left ventricular ejection fraction ( LVEF ) , left ventricular end-diastolic volume (LVEDV), left ventricular end-diastolic volume (LVEDV) and left ventricular end-diastolic volume (LVEDV) and anxiety and depression scores were compared between the two groups before and after treatment.Results The total effective rate of the treatment group was significantly higher than that of the control group (P<0.05).There was no serious adverse reaction in the two groups.The treatment compliance rate in the observation group was significantly better than that in the control group (P<0.05), and the level of cardiac function after treatment in the observation group was significantly better than the control group (P<0.05); observation group before and after treatment anxiety and depression scores were statistically significant (P<0.05), while the control group before and after treatment anxiety and depression score was not statistically significant.Results The combination of anti-angina pectoris and anxiety-depression drugs had better clinical curative effect on patients with angina pectoris and anxiety and depressive patients, and could effectively control the onset of angina pectoris.Meanwhile, they had higher safety and could improve the compliance of patients with clinical treatment.Anxiety and depression, so as to improve the quality of life of patients.

angina pectorisanxiety and depressionclinical efficacypsychological condition

江文华、石晓红、王志刚

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安吉县第二人民医院内科,浙江湖州313306

安吉县人民医院内科,浙江湖州313300

心绞痛 焦虑抑郁 临床疗效 心理状况

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(3)
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