目的 探讨反流性食管炎患者经埃索美拉唑、莫沙必利、镁加铝治疗后的临床效果.方法 选取2014年10月~2016年10月于象山中医院接受治疗的98例反流性食管炎患者,根据随机数字表法分为对照组和观察组,每组各49例.对照组患者仅采用埃索美拉唑、莫沙必利治疗;观察组患者则采用埃索美拉唑、莫沙必利、镁加铝联合治疗.对比2组治疗前后血清胃泌素、血清胃动素水平及食管内24 h pH值变化情况.结果 治疗后,观察组患者血清胃泌素、血清胃动素与对照组患者相比明显较高,差异有统计学意义(P<0.05);而观察组患者立位时pH值<4的总时间百分比、卧位时pH值<4的总时间百分比、pH值<4的总反流时间百分比、持续反流≥5 min的次数与对照组患者相比明显较低,差异有统计学意义(P<0.05).结论 反流性食管炎患者经埃索美拉唑、莫沙必利、镁加铝治疗的临床效果显著,可有效降低食管内24 h pH值,减少反流次数,提高血清胃泌素、血清胃动素水平.
Clinical efficacy of esomeprazole, mosapride, magnesium plus aluminum in reflux esophagitis
Objective To investigate clinical effect of esomeprazole, mosapride, magnesium plus aluminum in patients with reflux esophagitis. Methods 98 patients with reflux esophagitis who were treated in our hospital from October 2014 to October 2016 were selected and randomly divided into control group and observation group, with 49 cases in each group.In the control group, patients were treated with esomeprazole and mosapride.In the observation group, patients were given esomeprazole, mosapride and magnesium plus aluminum.The levels of serum gastrin, serum motilin and 24-hour pH in the esophagus were compared before and after treatment .Results After treatment,The levels of serum gastrin and serum motilin in the observation group were significantly higher than those in the control group, the difference was statistically significant (P<0.05), while the total time percentage of pH<4 at standing position, total time percentage of pH <4 at supine position, total reflux time percentage of pH <4, and the duration of continuous reflux≥five mins in the observation group were significantly lower than those in the control group, the difference was statistically significant (P<0.05). Conclusion Esomeprazole, mosapride and magnesium plus aluminum have significant clinical effect in patients with reflux esophagitis, and can effectively reduce 24-hour pH in the esophagus, decrease the number of reflux, increase serum gastrin and serum motilin levels.
reflux esophagitisesomeprazolemosapridemagnesium plus aluminumpH
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