羟苯磺酸钙联合复方血栓通胶囊治疗糖尿病性视网膜病变患者的临床效果

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NSTL
万方数据
维普

中文摘要：目的探讨羟苯磺酸钙联合复方血栓通胶囊治疗糖尿病性视网膜病变患者的临床疗效.方法选取2014年2月~2016年2月缙云县第二人民医院收治的糖尿病性视网膜病变患者112例,按照随机数字法随机分为观察组和对照组,每组56例.对照组给予复方血栓通胶囊进行治疗,观察组在对照组基础上给予羟苯磺酸钙片,口服,2组均治疗5个月,观察比较2组治疗前后血管瘤体积、黄斑厚度、出血斑面积、视野灰度值、视力情况、30°内阈值敏感程度,并对治疗前后血清hs-CRP、VEGF、IGF-1水平进行检测,同时对治疗后临床疗效及治疗期间不良反应进行评估.结果观察组治疗后总有效率为94.6%,显著性高于对照组的71.4%,差异具有统计学意义(P<0.05).治疗后,2组患者血管瘤体积、黄斑厚度、出血斑面积、视野灰度值、视力情况、30°内阈值敏感程度均显著改善(P<0.05),且观察组改善更为明显(P<0.05).治疗后2组hs-CRP、VEGF、IGF-1水平均较治疗前显著降低(P<0.05),且观察组低于对照组(P<0.05).2组患者的不良反应主要是胃肠道反应,不良反应发生率比较差异无统计学意义.结论羟苯磺酸钙联合复方血栓通胶囊可显著改善糖尿病性视网膜病变患者视野缺损症状,临床疗效好,安全性高,其作用机制可能与降低患者体内炎症因子水平有关.

外文标题：Effect of calcium dobesilate combined with compound Xueshuantong in patients with diabetic retinopathy

外文摘要：Objective To explore the clinical effects of calium dobesilate combined with compound thrombosis for patients with diabetic retinopathy due to visual field defect.Methods 112 cases of patients with diabetic retinopathy from February 2014 to February 2016 in our hospital were selected and randomly divided into the observation group and the control group,56 cases in each group.The control group were given compound Xueshuantong, while the observation group were treated with calcium dobesilate orally.And both the two groups were treated for five months.The hemangioma volume , macular thickness, hemorrhagic spot area, visual gray value, visual acuity, CRP, VEGF and IGF-1 levels in two groups were measured before and after treatment, as well as the clinical efficacy and adverse effects during the treatment.Results The total effective rate in the observation group was 94.6%significantly higher than that in the control group 71.4% (P<0.05).After treatment, in the two groups the hemangioma volume, macular thickness, hemorrhagic spot area, visual field gray value, visual acuity and 30°threshold sensitivity were significantly improved (P<0.05),but the improvement in the observation group was more (P<0.05).After treatment, the levels of hs-CRP, VEGF and IGF-1 were all significantly decreased (P<0.05), but the observation group decreased more significantly (P<0.05).Adverse reactions were mainly gastrointestinal reactions, and the incidence of adverse reactions in the two groups had no statistically significant difference.Couclusion Calcium dobesilate combined with compound thrombosis for patients with diabetic retinopathy due to visual field defect can improve the visual field defect of diabetic retinopathy patients.Its clinical effects is better and the safety is higher, which mechanism may be related to reducing the level of inflammatory factors in patients.

外文关键词：

calcium dobesilatecompound Xueshuantongdiabetic retinopathyvisual field defect

作者：

蔡玲敏、黄锦林、卢益丽

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作者单位：

浙江省丽水市缙云县第二人民医院内科,浙江丽水321404

关键词：

羟苯磺酸钙复方血栓通胶囊糖尿病性视网膜病变视野缺损

出版年：

2017

DOI：