鲑降钙素辅助治疗老年性骨质疏松症的临床疗效及对患者BMD和VAS评分的影响
Clinical effect of salmon calcitonin in the treatment of senile osteoporosis and its effect on BMD and VAS scores
殷法东 1汤华林 2校佰平3
作者信息
- 1. 象山县红十字台胞医院骨科,浙江宁波315731
- 2. 宁波大学医学院附属医院骨科,浙江宁波315000
- 3. 宁波市第六医院骨科,浙江宁波315000
- 折叠
摘要
目的 探讨鲑降钙素辅助治疗老年性骨质疏松症患者的临床疗效,并观察其对患者骨密度(BMD)及疼痛的改善作用.方法 回顾性分析2015年9月~2016年9月象山县红十字台胞医院收治的180例诊断为骨质疏松症患者临床资料,按照随机数字表法将其分为对照组与治疗组,各90例.对照组给予碳酸钙D3、阿仑膦酸钠和辛伐他汀片治疗,治疗组在对照组治疗基础上给予鲑鱼降钙素.2组均治疗6w.检测并比较2组患者治疗前、后腰椎、股骨及桡骨骨密度,评价2组患者治疗前、后疼痛程度、功能障碍情况和生活质量评分,比较2组临床治疗效果及不良反应情况.结果 治疗组总有效率94.44%,明显高于对照组75.56%(P<0.05).治疗后,治疗组腰椎骨密度、股骨骨密度及桡骨骨密度明显高于对照组(P<0.05);治疗组自发腰背疼痛、前屈后伸痛、翻身痛及负重痛明显低于对照组(P<0.05).治疗组ODI指数明显低于对照组(P<0.05).2组患者治疗后各项生活质量评分明显高于治疗前,且治疗组高于对照组(P<0.05).治疗期间2组均无明显不良反应发生.结论 鲑降钙素辅助治疗老年性骨质疏松症患者疗效显著,有利于改善患者骨密度、减轻疼痛及改善其功能障碍,具有较高安全性.
Abstract
Objective To investigate the clinical effect of salmon calcitonin in the treatment of senile osteoporosis , and to observe the effect of salmon calcitonin on bone mineral density ( BMD ) and pain.Methods 180 cases of patients diagnosed as osteoporosis from September 2015 to September 2016 in our hospital were retrospectively analyzed, the patients were divided into control group and treatment group according to the random number table method.The clinical efficacy and side effects of the two groups were evaluated.The bone mineral density (BMD) of the lumbar vertebrae, femur and radius were measured by dual energy X-ray absorptiometry.The VAS was used to evaluate the two groups before and after the treatment.( ODI) were used to evaluate the functional status of the patients before and after treatment.The self-made questionnaire was used to evaluate the quality of life of the patients before and after treatment.Results The total effective rate of treatment group was 94.44%, significantly higher than the control group 75.56%(P<0.05).After treatment, the treatment group of lumbar spine bone mineral density, bone mineral density and radial bone mineral density was significantly higher than the control group (P<0.05).After treatment, spontaneous low back pain, flexion extension pain, turn over pain and weight pain were significantly lower in the treatment group than in the control group (P<0.05).The ODI index of the treatment group was significantly lower than that of the control group (P<0.05).After treatment, the quality of life scores in the two groups were significantly higher than those before treatment, and the treatment group was higher than the control group(P<0.05).No significant adverse reactions occurred in two groups during the treatment.Conclusion Salmon calcitonin treatment of osteoporosis in elderly patients with a significant effect, help to improve bone mineral density, reduce pain and improve its dysfunction, and has high security.
关键词
鲑降钙素/老年性骨质疏松/疼痛/功能障碍/骨密度Key words
salmon calcitonin/senile osteoporosis/pain/dysfunction/bone mineral density引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据