三乙醇胺乳膏治疗创伤性伤口的效果及对患者IL-2、IL-8、TNF-α水平的影响
Effect of triethanolamine cream in treatment of wound healing and its effect on level of IL-2 , IL-8 and TNF-α
王鹏 1柳鑫 2程盼3
作者信息
- 1. 蕲春人民医院,湖北蕲春435300
- 2. 武汉市普爱医院,湖北武汉430030
- 3. 上海景峰制药有限公司,上海201908
- 折叠
摘要
目的 研究三乙醇胺乳膏对创伤性伤口患者的临床疗效及对IL-2、IL-8、TNF-α水平的影响.方法 选取2015年2月~2016年1月蕲春人民医院收治的88例创伤伤口患者,按照投硬币法分为观察组和对照组,每组44例.对照组采取藻酸盐敷料进行治疗,观察组使用三乙醇胺乳膏进行治疗.比较2组患者IL-2、IL-8、、TNF-α水平及视觉模拟评分(VAS)变化,评判2组患者临床疗效.结果 治疗后,观察组总的有效率为90.91%,显著高于对照组68.18%,差异具有统计学意义(P<0.05).治疗后5、10、20 d,2组患者VAS评分均显著降低(P<0.05),其中观察组在治疗后5、10、20d的VAS评分显著低于对照组(P<0.05).观察组的IL-2水平显著高于对照组,IL-8、TNF-α水平显著低于对照组,差异均有统计学意义(P<0.05).结论 三乙醇胺乳膏治疗创伤伤口患者,可升高患者IL-2水平,降低IL-8、TNF-α水平,能有效缓解患者疼痛感,临床疗效良好.
Abstract
Objective To study the clinical effect of triethanolamine cream in treatment of traumatic wounds and its effect on level of interleukin-2 (IL-2), interleukin-8 (IL-8) and tumor necrosis factor-α(TNF-α).Methods 88 patients with traumatic wounds were selected in our hospital from February 2015 to January 2016, those patients were divided into observation group and control group according to coin method.The control group was treated with alginate dressing, observation group were given triethanolamine cream for treatment.The levels of IL-2, IL-8, TNF-αand visual analogue scale(VAS) between the two groups were compared.The clinical curative effect of the two groups was evaluated.Results After treatment, the total effective rate of the observation group(90.91%) was significantly higher than the control group (68.18%).There were no significant differences in VAS scores between the two groups before treatment, 5, 10,20 days after treatment, the VAS scores of the two groups were significantly lower than before treatment (P<0.05), at 5,10,20 days after treatment, the VAS scores in the observation group were significantly lower than the control group (P<0.05).The level of IL-2 in the observation group were significantly higher than the control group, the levels of IL-8,TNF-αwere significantly lower than the control group (P<0.05).Conclusion Triethanolamine cream can increase the level of IL-2 and decrease the levels of IL-8 and TNF-αin patients with traumatic wounds, it can relieve the pain of patients and has good clinical curative effect.
关键词
三乙醇胺乳膏/创伤/白介素-2/白介素-8/肿瘤坏死因子-αKey words
triethanolamine cream/trauma/interleukin-2/interleukin-8/tumor necrosis factor-α引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据