枸橼酸莫沙必利片对胃食管反流病患者胃泌素的影响
Effect of mosxapride citrate on gastrin in patients with gastroesophageal reflux
李学琴 1高建康2
作者信息
- 1. 山西省阳泉市第二人民医院内一科,山西阳泉045011
- 2. 山西省阳泉市第一人民医院内分泌科,山西阳泉045000
- 折叠
摘要
目的 研究枸橼酸莫沙必利片对胃食管反流病患者胃泌素的影响,并分析其临床疗效.方法 选取2013年8月~2016年8月山西省阳泉市第二人民医院收治的86例胃食管反流病患者,随机分为观察组和对照组,每组43例.对照组在基础治疗上使用埃索美拉唑进行治疗,观察组在对照组治疗基础上给予枸橼酸莫沙必利片进行治疗.分析2组患者临床疗效和不良反应,比较2组患者治疗前后视觉模拟评分(VAS)、胃泌素、胃动素变化.结果 治疗后,观察组总有效率显著高于对照组[90.70%(39/43)vs.65.12%(28/43)](P<0.05);观察组的VAS评分明显低于对照组[(2.43±0.25)vs.(4.02±0.41)](P<0.05);观察组胃泌素、胃动素水平显著高于对照组[(55.87±4.82)pg/mL、(308.43±19.31)pg/mL vs.(44.12±3.86)pg/mL、(243.12±15.76)pg/mL](P<0.05).2组不良反应发生率比较差异无统计学意义.结论 枸橼酸莫沙必利片治疗胃食管反流病患者临床疗效良好,能有效改善胃泌素水平和临床症状,且不良反应率低.
Abstract
Objective To study the effect of mosapride citrate in the treatment of gastroesophageal reflux disease and its effect on gastrin .Methods 86 patients with gastroesophageal reflux disease admitted in our hospital from August 2013 to August 2016, those patients were divided into observation group and control group according to the order of admission,43 cases in each group.The control group was treated with esomeprazole on the basis of basal therapy, and the observation group was treated with mosapride citrate on the basis of control group.The clinical curative effect and adverse reaction were analyzed,visual analogue scale(VAS), gastrin and motilin were compared before and after treatment between the two groups.Results After treatment, the total effective rate in the observation group was significantly higher than the control group [90.70% (39/43) vs.65.12% (28/43)](P<0.05). The VAS score in the observation group was significantly lower than the control group [(2.43 ±0.25) vs.(4.02 ±0.41)](P<0.05).The levels of gastrin and motilin in the observation group were significantly higher than the control group[ (55.87 ±4.82) pg/mL, (308.43 ±19.31) pg/mL vs. (44.12 ±3.86) pg/mL,(243.12 ±15.76) pg/mL](P<0.05).There was no significant difference in adverse reaction rate between two groups. Conclusion Mosapride citrate tablets can be used in gastroesophageal reflux disease , can effectively improve the patient's gastrin levels and clinical symptoms, clinical efficacy is good, and with low rate of adverse reactions.
关键词
枸橼酸莫沙必利片/胃食管反流病/胃泌素/疗效Key words
mosapride citrate tablets/gastroesophageal reflux disease/gastrin/efficacy引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据