盐酸埃克替尼联合调强放疗对晚期肺癌患者CEA、NSE、CA199水平的影响
Effects of exectin hydrochloride combined with intensity modulated radiotherapy on CEA, NSE and CA199 levels in advanced lung cancer
金晓辉 1张明 1许晴1
作者信息
- 1. 武警浙江省总队嘉兴医院呼吸科,浙江嘉兴314000
- 折叠
摘要
目的 研究盐酸埃克替尼联合调强放疗对晚期肺癌患者癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、血清糖蛋白抗原199(CA199)水平的影响.方法 选取2014年6月~2016年6月武警浙江省总队嘉兴医院收治的88例晚期肺癌患者,根据随机数字法分为观察组和对照组,每组各44例.对照组采用调强放疗进行治疗,观察组在此基础上联合盐酸埃克替尼进行治疗.比较2组患者临床疗效和不良反应,分析2组患者治疗前后CEA、NSE、CA199水平变化.结果 治疗后,观察组总有效率84.09%,显著高于对照组52.27%,差异有统计学意义(P<0.05).治疗前,2组患者CEA、NSE、CA199水平比较无显著性差异,治疗后,2组患者CEA、NSE、CA199水平较治疗前显著降低,差异有统计学意义(P<0.05),观察组的CEA、NSE、CA199水平显著低于对照组,差异有统计学意义(P<0.05).观察组和对照组的Ⅰ-Ⅱ度、Ⅲ-Ⅳ度肝功能受损、胃肠道反应、骨髓抑制、急性放射性肺炎不良反应率比较差异无统计学意义.结论 盐酸埃克替尼联合调强放疗能有效降低晚期肺癌患者CEA、NSE、CA199水平,临床疗效良好,不会增加不良反应率.
Abstract
Objective To study effects of exectin hydrochloride and intensity modulated radiotherapy in treatment of patients with advanced lung cancer and its effect on levels of carcinoembryonic antigen (CEA), neuron-specific enolase (NSE) and serum glycoprotein antigen 199 (CA199). Methods 88 patients with advanced lung cancer were selected from June 2014 to June 2016 in our hospital were selected and randomly divided into observation group and control group, 44 cases in each group.In the control group, the patients were treated with IMRT, and the observation group was treated with exectin hydrochloride on the basis of control group.The clinical efficacy and adverse reaction were compared between the two groups.The levels of CEA, NSE and CA199 before and after treatment were analyzed.Results After treatment, the total effective rate in the observation group 84.09% was significantly higher than the control group 52.27%, the difference was statistically significant (P<0.05).Before treatment, the levels of CEA, NSE and CA199 of the two groups had no significantly different, after treatment, the levels of CEA, NSE and CA199 of the two groups were significantly lower than before treatment, the difference was statistically significant (P<0.05).CEA, NSE, CA199 levels in the observation group were significantly lower than the control group, the difference was statistically significant (P<0.05).There was no significant difference in adverse reaction rate of I-II, III-IV liver function, gastrointestinal reaction, bone marrow suppression and acute radiation pneumonitis in observation group and control group.Conclusion Ectectin hydrochloride combined with intensity modulated radiotherapy can effectively reduce the levels of CEA, NSE and CA199 in patients with advanced lung cancer, and the clinical efficacy is good, and will not increase the adverse reaction rate.
关键词
盐酸埃克替尼/调强放疗/肺癌/癌胚抗原/神经元特异性烯醇化酶/血清糖蛋白抗原199Key words
exectin hydrochloride/intensity modulated radiotherapy/lung cancer/carcinoembryonic antigen/neuron-specific enolase/serum glycoprotein antigen 199引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据