ABCF2在卵巢癌组织中的阳性表达及其与化疗耐药的关系
ABCF2 positive expression and its relationship with chemotherapy resistance in ovarian carcinoma
陈旭伟 1朱滔 1厉华卿1
作者信息
- 1. 东阳人民医院妇科,浙江东阳322100
- 折叠
摘要
目的 探讨三磷酸腺苷结合盒转运蛋白F2(ATP binding cassette transporter protein F2,ABCF2)在卵巢癌组织中的阳性表达及其与化疗耐药的关系.方法 选取91例卵巢癌患者切除标本,同时选取42例距肿瘤5cm癌旁组织作为正常对照,采用免疫组化染色法检测各标本ABCF2表达情况,分析ABCF2阳性表达与卵巢癌患者临床病理特征的关系.结果 卵巢癌组织ABCF2阳性表达率为68.13%,明显高于正常卵巢组织9.52%,差异比较有统计学意义(P<0.05);ABCF2阳性表达与卵巢癌患者年龄、组织类型无关;Ⅲ期~Ⅳ期患者ABCF2阳性表达率为86.54%,明显高于Ⅰ期~Ⅱ期43.59%,差异比较有统计学意义(P<0.05);化疗耐药患者ABCF2阳性表达率为88.89%,明显高于化疗敏感患者59.38%,差异比较有统计学意义(P<0.05);Logistic回归分析结果显示ABCF2阳性表达是卵巢癌耐药的独立影响因素(OR=4.586,95%CI:1.121~3.392,P<0.05).结论 ABCF2在卵巢癌组织中高表达,其可能与卵巢癌患者发生化疗耐药有关.
Abstract
Objective To investigate the positive expression of ATP binding cassette transporter protein F2 (ABCF2) in ovarian cancer tissue and its relationship with chemotherapy resistance.Methods 91 patients with ovarian cancer specimens were selected and 42 cases from the tumor 5cm adjacent tissues as normal controls, ABCF2 expression in each sample was detected by immunohistochemical staining , the relationship between ABCF2 expression and clinicopathological features of patients with ovarian cancer were analyzed .Results The positive expression rate of ABCF2 in ovarian cancer tissue was 68.13%, which was significantly higher than that in normal ovarian tissue (9.52%), and the difference was statistically significant (P<0.05).The positive expression of ABCF2 was not related to the age and organization type of ovarian cancer patients.The positive expression rate of ABCF2 in stage III~IV was 86.54%, which was significantly higher than that of phase I~II (43.59%), the difference was statistically significant (P<0.05). The positive expression rate of ABCF2 in patients with chemotherapy resistance was 88.89%, which was significantly higher than that in patients with chemotherapy sensitivity ( 59.38%) , and the difference was statistically significant ( P<0.05 ) .The results of Logistic regression analysis showed that ABCF2 positive expression was the independent influencing factor of ovarian cancer drug resistance (OR =4.586,95% CI:1.121 ~3.392,P<0.05). Conclusion ABCF2 is highly expressed in ovarian cancer, which may be associated with chemotherapy resistance in patients with ovarian cancer .
关键词
三磷酸腺苷结合盒转运蛋白F2/卵巢癌/化疗耐药Key words
ATP binding cassette transporter F2/ovarian cancer/chemotherap resistance引用本文复制引用
基金项目
吴阶平医学基金会临床科研资金项目(2011-427-207)
出版年
2017
NETL
NSTL
维普
万方数据