microRNAs在肿瘤治疗中的研究现状
Current Status of microRNA in tumor therapy
董俊丽 1刘剑敏1
作者信息
- 1. 武汉市第一医院药学部,湖北武汉430022
- 折叠
摘要
microRNAs是一类非编码RNA,被认为是转录后水平的基因表达调控子.这类内生的非编码RNA在肿瘤细胞中呈现异常表达,在肿瘤细胞的生长、繁殖、凋亡以及转移等进程起着重要的调控作用.目前,miRNAs作为癌症诊断和预后的一个重要的生物学参考,已受到广泛观注.本文将介绍miRNA在肿瘤基因表达中的重要作用以及利用miRNA作为肿瘤靶向治疗临床应用前需要解决的问题.
Abstract
microRNAs is a class of non-coding RNA, which is the transcriptional regulator of gene expression at the post transcriptional level.These endogenous non-coding RNA are expressed abnormally in tumor cells, in the tumor cell growth, reproduction, apoptosis and metastasis and other processes play an important regulatory role.Recently, microRNAs was widely regarded as biological diagnostic and prognostic markers of tumor in clinic, has been widely viewed.This article will introduce the important role of miRNA in tumor gene expression, as well as the use of miRNA as a tumor targeted therapy clinical application before the need to solve the problem .
关键词
microRNA/肿瘤/生物标志/靶向治疗Key words
microRNA/tumor/biomarker/targeted therapy引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据