首页|左旋甲状腺素与硒酵母联合治疗淋巴细胞性甲状腺炎的疗效观察

左旋甲状腺素与硒酵母联合治疗淋巴细胞性甲状腺炎的疗效观察

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目的 分析左旋甲状腺素与硒酵母联合治疗淋巴细胞性甲状腺炎患者的临床效果.方法 回顾性分析吉林省梅河口市中心医院2015年3月~2016年9月期间收治的96 例淋巴细胞性甲状腺炎患者的临床资料,根据双盲法将其分为研究组(48 例)与对照组(48 例).对照组给予左旋甲状腺素治疗,研究组给予左旋甲状腺素与硒酵母联合治疗;对比2 组游离四碘甲状腺原氨酸(FT4)、游离三碘甲状腺原氨酸(FT3)、促甲状腺素(TSH)、甲状腺球蛋白抗体(TGAb)、血清甲状腺过氧化物酶抗体(TPOAb)、外周血T 细胞亚群水平变化状况以及治疗总有效率.结果 治疗后2 组FT4、FT3、TSH、TGAb、TPOAb 水平明显更优,治疗前后差异有统计学意义( P<.0.05);研究组的总有效率显著高于对照组,差异有统计学意义( P< 0.05).结论 左旋甲状腺素与硒酵母联合治疗淋巴细胞性甲状腺炎患者的临床效果显著,值得推广运用.
Clinical observation of L-Thyroxine combined with selenium yeast in treating lymphocytic thyroiditis
Objective To analyze the clinical effect of L-thyroxine combined with selenium yeast in patients with lymphocytic thyroiditis.Methods The clinical data of 96 patients with lymphocytic thyroiditis from March 2015 to September 2016 was analyzed retrospectively.The cases were divided into study group(48 cases)and control group(48 cases)according to double-blind method.The control group were treated with levothyroxine and the study group were treated with levothyroxine combined with selenium yeast.Free tetraiodothyronine(FT4),free triiodothyronine(FT3),thyrotropin(TSH),thyroglobulin antibody(TGAb),serum thyroid peroxidase antibody(TGAb)and serum thyroid peroxidase(TPOAb),the level of peripheral blood T cell subsets and the total effective rate between the two groups were compared.Results After treatment,the levels of FT4,FT3,TSH,TGAb and TPOAb in the two groups were significantly better than those before treatment(P<0.05).FT4,FT3,TSH,TGAb,TPOAb levels in the study group were significantly better than that in the control group(P<0.05).Compared with the control group,the T lymphocyte subsets of the study group after treatment were significantly better(P<0.05).Compared with the control group,the total effective rate of the study group was significantly higher(P<0.05).Conclusion The effect of L-thyroxine combined with selenium yeast in the treatment of lymphocytic thyroiditis patients is very significant.The treatment method is worthy of promotion in the clinical treatment.

levothyroxineselenium yeastlymphocytic thyroiditis

成日光、李永秀、李相哲、徐鹏、张旭

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吉林省梅河口市中心医院 普外科,吉林 梅河口 135000

左旋甲状腺素 硒酵母 淋巴细胞性甲状腺炎

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(4)
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