目的 探讨葛根芩连汤联合黄连素对双胍类药物抵抗老年2型糖尿病患者血清糖化血红蛋白及同型半胱氨酸水平的影响.方法 选取2015年3月～2016年3月杭州市江干区人民医院收治的对二甲双胍类药物抵抗的老年2型糖尿病患者82例,随机分为2组,对照组予常规治疗,实验组在对照组的治疗基础上加用葛根芩连汤联合黄连素治疗,共治疗2 w.观察2组患者治疗前后FPG、2 h PG、血清HbA1c、Hcy、hs-CRP、APN、TNF-α、ICAM-1水平及临床疗效.结果 与治疗前比较,2组患者治疗后的FPG、2 h PG、HbA1c、血清Hcy、hs-CRP、TNF-α、ICAM-1水平均明显降低(P<0.05),血清APN水平明显升高(P<0.05);与对照组比较,实验组的FPG、2 hPG、HbA1c、血清Hcy、hs-CRP、TNF-α、ICAM-1水平均较低(P<0.05),血清APN水平较高(P<0.05);实验组临床总有效率显著高于对照组(P<0.05).结论 葛根芩连汤联合黄连素能有效降低老年双胍类药物抵抗2型糖尿病患者的FPG、2 hPG、HbA1c、血清Hcy、hs-CRP、TNF-α、ICAM-1水平,提高血清APN水平,临床疗效较好.
Effect of Gegenqinlian decoction combined with berberine in the treatment of biguanides resistant type 2 diabetes in elderly patients in glycosylated hemoglobin and homocysteine
Objective To investigate the effects of Gegenqinlian decoction combined with berberine in the treatment of biguanides resistant type 2 diabetes in elderly patients in glycosylated hemoglobin and homocysteine.Methods 82 elderly patients from March 2015 to March 2016 in our hospital who were diagnosed with type 2 diabetes with biguanides resistant were selected,and randomly divided into two groups,41 cases in each groups.Control group receiced routine treatment,experimental group received more with Gegenqinlian Decoction combined with berberine treatment,and all the patients were treated for two weeks.Levels of FPG,2h PG,serum HbA1c,Hcy,hs-CRP,APN,TNF-α,ICAM-1 and clinical efficacy were compared,and the results were analyzed by statistical software SPSS 19 data analysis.ResultsCompared with before treatment,levels of serum FPG,2h PG,HbA1c,Hcy,hs-CRP,TNF-α and ICAM-1decreased in two groups after the treatment(P<0.05),levels of AFN increased(P<0.05),Compared with the control group,levels of serum FPG,2hPG,HbA1c,Hcy,hs-CRP,TNF-α and ICAM-1 in the experiment group were lower(P<0.05),levels of AFN were higher(P<0.05);The total effective rate of the experimental group was significantly higher than the control group(P<0.05).Conclusion Gegenqinlian decoction combined with berberine can effectively reduce the levels of FPG,2h PG,HbA1c,Hcy,hs-CRP,TNF-α in serum and ICAM-1 levels,increase serum APN level,and good curative effect,worthy of clinical application and promotion.
NETL
NSTL
万方数据
维普
