摘要
目的 探究通幽汤加减联合FOLFOX4方案对晚期前列腺癌患者前血栓状态和临床疗效的影响.方法 选取142例晚期前列腺癌患者,随机分成研究组和对照组,各71例.对照组给予6 w的FOLFOX4方案化疗,研究组在对照组基础上给予通幽汤加减口服.治疗后对患者血清同型半胱氨酸(Hcy)、D-二聚体(D-D)、纤维蛋白原(FIB)水平、血流变水平、临床疗效、1年内静脉血栓发生率、6个月生存率、1年生存率进行统计比较.结果 治疗后,与对照组比较,研究组Hcy、D-D、FIB、全血高切黏度、全血中切黏度、全血低切黏度、血浆黏度、1年内静脉血栓发生率较高,差异有统计学意义(P<0.05);研究组红细胞变形指数、有效率、1年生存率较高,差异有统计学意义( P <0.05).结论 通幽汤加减联合FOLFOX4方案化疗治疗晚期前列腺癌可改善患者前血栓状态,能提高治疗效果,降低患者静脉血栓发生率,增加1年生存率.
Abstract
Objective To analyze the effect of modified Tongyou decoction combined with FOLFOX4 chemotherapy on pre-thrombus state and curative effect of patients with advanced prostatic cancer.Methods 142 patients with advanced prostatic cancer were collected,all patients were randomly divided into study group and control group,71 cases in each group.The control group was given FOLFOX4 chemotherapy and the study group was given modified Tongyou decoction on the baseis of the control group.After treatment,the serum levels of homocysteine(Hcy),D-two dimer(D-D),fibrinogen(FIB),the level of hemorrheology,clinical effect,the incidence of venous thrombosis in one years,the six month survival rate,the one year survival rate were detected in all patients.Resutls After treatment,compared with control group,the serum levels of Hcy,D-D,FIB,the whole blood high,middle and low-shear viscosities,plasma viscosity and the incidence of venous thrombosis in one years were higher in the study group and the difference was statistically significant(P<0.05);the erythrocyte deformability index,effective rate and one year survival rate were higher were higher in the study group and the difference was statistically significant(P<0.05).Conclusion The modified Tongyou decoction combined with FOLFOX4 chemotherapy in treatment of patients with advanced prostatic cancer can improve the prethrombotic state,improve the therapeutic effect,reduce the incidence of venous thrombosis and increase the one year survival rate,and have a guiding significance for clinic.
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NSTL
维普
万方数据