摘要
目的 探讨妇科千金片联合孕激素对功能性子宫出血患者血清免疫球蛋白、血清IL-2及其可溶性受体水平的影响,以期探寻治疗功能性子宫出血患者的最佳方案.方法 选择2015年6月～2016年6月期间在本院确诊为功能性子宫出血的98例患者纳入研究,随机分为观察组和对照组,各49例.对照组患者给予孕激素口服治疗,观察组在对照组治疗的基础上联合妇科千金片治疗,对比2组患者治疗前后的月经情况、血清中免疫球蛋白IgM、IgA、血清IL-2及其可溶性受体水平.结果 治疗后第1个月、第2个月、第3个月时,观察组患者的月经量分别为(103.5±21.5)mL、(93.5±14.7)mL、(81.4±12.2)mL,均显著低于对照组的月经量;观察组患者的月经期分别为(7.68±0.92)d、(6.81±0.87)d、(6.14±0.78)d,均显著短于对照组的月经期;治疗后第1个月、第2个月、第3个月时,观察组患者血清中IgA、IgM水平分别为(3.6±0.8)、(2.6±0.8)、(1.8±0.3)和(2.9±0.5)、(2.2±0.3)、(1.1±0.2),均明显低于对照组患者,差异显著,具有统计学意义;治疗后第1个月、第2个月、第3个月时,观察组患者的血清IL-2及其可溶性受体水平显著低于对照组.结论 妇科千金片联合孕激素可以改善功能性子宫出血患者免疫功能,降低炎症水平及其可溶性受体水平,相比单用孕激素治疗效果更好.
Abstract
Objective To investigate the effect of Fukeqianjin tablets combined with progesterone on serum immunoglobulin,serum IL-2 and soluble receptor levels in patients with functional uterine bleeding,and to explore the optimal regimen for patients with functional uterine bleeding.Methods A total of 98 patients with functional uterine bleeding diagnosed in our hospital from June,2015 to June,2016 were randomLy divided into observation group and control group(n=49).The patients in the control group were treated with oral progesterone and the observation group.The control group was treated on the basis of the combination of gynecological Qianjin Tablet,compared the two groups of patients before and after treatment of menstrual conditions,serum IgM,IgA,serum IL-2 and soluble receptor levels.Results In the first month,the second month and the third month after treatment,the menstrual volume in the observation group were(103.5±21.5)mL,(93.5±14.7)mL,(81.4± 12.2)(7.68±0.92)d,(6.81±0.87)d and(6.14±0.78)d respectively in the observation group were significantly shorter than those in the control group(P<0.05).After treatment,the menstrual period The serum levels of IgA and IgM were(3.6±0.8),(2.6±0.8),(1.8±0.3)and(2.9±0.5),(2.2±0.3),(1.1±0.2)in the first month,the second month and the third month respectively,Significantly lower than the control group,the difference was statistically significant; the first month after treatment,the first two months,the first three months,observation group of patients with serum IL-2 and soluble receptor levels significantly Lower than the control group.Conclusion Fukeqianjin tablets combined with progesterone can improve the immune function of patients with functional uterine bleeding,reduce the level of inflammation and soluble receptor levels,compared with single progesterone treatment better,the program better.
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