目的 研究温胃降逆颗粒联合尿囊素铝对消化性溃疡患者的临床疗效及对血清胃泌素(Gas)、转化生长因子-α(TGF-α)和白介素-8(IL-8)的影响,以探索对消化溃疡患者的最佳治疗方案.方法 选取2014年7月～2015年7月宁波市北仑区人民医院接诊的86例消化性溃疡患者作为本次研究对象.对照组采用尿囊素铝治疗,观察组采用温胃降逆颗粒联合尿囊素铝治疗,观察2组患者治疗后血清Gas、TGF-α、IL-8,不良反应,治疗疗效.结果 治疗后,观察组Gas、IL-8小于对照组,TGF-α大于对照组[(68.96±21.26)pg/mL vs.(82.75±24.08)pg/mL、(6.93±2.31)μg/L vs.(5.06±2.07)μg/L、(11.86±2.10)μg/L vs.(14.97±2.76)μg/L]( P <0.05);观察组不良反应总发生率小于对照组6.97％(3/43)vs.23.25％(10/43)( P <0.05);观察组总有效率优于对照组95.34％(41/43)vs.76.74％(33/43)( P <0.05).结论 温胃降逆颗粒联合尿囊素铝治疗能够改善消化溃疡患者的溃疡面,提高Gas、TGF-α,降低IL-8,比单用尿囊素铝疗效更显著,方案更优.
Curative efficacy of Wenweijiangni granule combined with Aldioxa in treatment of peptic ulcer and its effects on serum Gas, TGF-α and IL-8 levels
Objective To study the clinical efficacy of Wenweinjiangni granule combined with allantoin aluminum on patients with peptic ulcer and the changes of serum gastrin,transforming growth factor-α(TGF-α)and interleukin-8(IL-8)to explore the best treatment for patients with peptic ulcer.Methods 86 patients with peptic ulcer admitted in our hospital from July 2014 to July 2015 were selected as subjects of this study.The control group was treated with allantoin aluminum,and the observation group was treated with Wenweijiangni granule combined with allantoin.The serum levels of Gas,TGF-α,IL-8,adverse reaction and therapeutic effect were observed in the two groups.Results After treatment,the levels of Gas and IL-8 in the observation group were significantly lower than those in the control group [(68.96±21.26)pg/mL vs.(82.75±24.08)pg/mL(6.93±2.31)μg/L vs.(5.06±2.07)μg/L,(11.86±2.10)μg/L vs.(14.97±2.76)μg/L](P<0.05).The total incidence of side effects in the observation group was less than that in the control group(6.97％vs.23.25％)(P<0.05).The total effective rate of the observation group was better than that of the control group(95.34％vs.76.74％)(P<0.05).Conclusion The combination of Wenweijiangni granule and allantoin aluminum can improve the ulcer surface of patients with peptic ulcer,improve Gas,TGF-α and IL-8,which is more effective and more effective than aluminum allantoin alone.
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