寒喘祖帕颗粒联合沙丁胺醇雾化吸入治疗小儿支气管哮喘的疗效及对血清MPO、PMN、MCP-4的影响
Effect of Hanchuan Zupa granule combined withventolin atomizing inhalation in infantile bronchial asthma and the influence of serum MPO, PMN, MCP-4
吴丽梅 1黄丽素 1徐兰飞2
作者信息
- 1. 义乌市妇幼保健计划生育服务中心儿科,浙江 义乌 322000
- 2. 上海交通大学医学院附属新华医院儿科,上海 200092
- 折叠
摘要
目的 探讨寒喘祖帕颗粒联合沙丁胺醇雾化吸入治疗小儿支气管哮喘的疗效及对血清髓过氧化物酶(MPO)、中性粒细胞(PMN)、单核细胞趋化蛋白-4(MCP-4)的影响.方法 选择2015年6月～2016年6月于义乌市妇幼保健计划生育服务中心就诊的92例小儿支气管哮喘患儿,按抽签法分为对照组(n=46)与实验组(n=46),对照组采用沙丁胺醇雾化吸入,实验组在对照组基础上加用寒喘祖帕颗粒,观察2组疗效,MPO、PMN、MCP-4,炎性因子,T淋巴细胞亚群,动脉血气指标,临床表现消失时间和安全性.结果 治疗后,实验组总有效率为93.48%,高于对照组的76.08%,差异有统计学意义(P<0.05);实验组MPO、PMN及MCP-4低于对照组,差异有统计学意义(P<0.05).实验组炎性因子、T淋巴细胞亚群、动脉血气指标较对照组改善更明显,差异有统计学意义(P<0.05).实验组临床表现消失时间优于对照组,差异有统计学意义(P<0.05).2组安全性比较差异无统计学意义.结论 寒喘祖帕颗粒联合沙丁胺醇雾化吸入治疗小儿支气管哮喘的疗效确切,下调血清MPO、PMN、MCP-4表达,促进患儿恢复.
Abstract
Objective To investigate thecurative effect of Hanchuan Zupa granule combined with ventolin atomizing inhalation in the treatment of infantile bronchial asthma and the influence of serum myeloperoxidase(MPO),neutrophil(PMN),monocyte chemotactic protein-4(MCP-4).Methods 92 cases of infantile bronchial asthma from June 2015 to June 2016 in yiwu materal and child health care family planning senice center,according to the draw method was divided into the control group(n=46)and experimental group(n=46),the control group was treated with salbutamol inhalation,and the experimental group was based on control group treated with Hanchuan Zupa granule,the curative effect,MPO,PMN,MCP-4,inflammatory factor,the T lymphocyte subgroup,arterial blood gas index,clinical symptoms disappeared time and safety of two groups were observed.Results After treatmented,the total effective rate of experimental group was 93.48％higher than that of control group 76.08％,the difference was statistically significant(P<0.05).The MPO,PMN,MCP-4 of experimental group was lower than the control group,the difference was statistically significant(P<0.05).The inflammatory factor,T lymphocyte subgroup,arterial blood gas index in the experimental group were more significantly improved than those in the control group,the difference was statistically significant(P<0.05).The clinical symptoms disappear time of experimental group was better than that of control group,the difference was statistically significant(P<0.05).There was no significant difference in safety between the two groups.Conclusion Hanchuan Zupa granule combined withventolin atomizing inhalation of children with bronchial asthma in the exact effect,and down-regulated the expression of MPO,PMN,MCP-4,promote the recovery of children.
关键词
寒喘祖帕颗粒/沙丁胺醇/小儿支气管哮喘/疗效/血清指标Key words
Hanchuan Zupa granule/ventolin/infantile bronchial asthma/curative effect/serum index引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据