氟康唑胶囊联合知柏地黄丸对滴虫性阴道炎患者血清IL-10,TNF-α及临床疗效的影响
Effect of fluconazole capsules combine with Zhibai dihuangwan on serum IL-10, TNF-α and clinical effect on trichomonas vaginitis patients
王芬萍 1王军2
作者信息
- 1. 宁波市北仑区小港医院 妇产科,浙江 宁波 315803
- 2. 上海市第六医院妇产科,上海 200233
- 折叠
摘要
目的 探讨氟康唑胶囊联合知柏地黄丸对滴虫性阴道炎患者血清IL-10,TNF-α及临床疗效的影响.方法 选取2015年3月～2016年6月宁波市北仑区小港医院就诊的78例滴虫性阴道炎患者,随机分为实验组和对照组2组,各39例.对照组患者给予氟康唑胶囊0.2 g/次,1次/天;实验组患者在对照组的基础上给予知柏地黄丸8丸/次,3次/天,治疗连续4 w.观察并比较2组患者治疗前后白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、患者阴道健康评分以及患者临床疗效水平.结果与治疗前相比,2组患者治疗后IL-10、TNF-α水平均下降,差异具有统计学意义(P<0.05);与对照组相比,实验组患者IL-10、TNF-α水平较低,差异具有统计学意义(P<0.05).与治疗前相比,2组患者治疗后阴道健康评分均升高,差异具有统计学意义(P<0.05);与对照组相比,实验组患者阴道健康评分较高,差异具有统计学意义(P<0.05);与对照组相比,实验组患者的临床治疗总有效率较高,差异具有统计学意义(P<0.05).结论 氟康唑胶囊联合知柏地黄丸能够降低滴虫性阴道炎患者血清IL-10,TNF-α水平,改善患者临床症状,临床疗效较好.
Abstract
Objective To investigate the fluconazole capsule combined with Zhibaidihuangwan on Trichomonas vaginitis patients on serum IL-10,TNF-α and clinical effect.Methods 78 cases of trichomonas vaginitis patients were collected in our hospital,randomly divided into two groups: experimental group and control group,with 39 cases in each.After admission,the patients in the control group received fluconazole 0.2g,onetimes aday; patients in the experimental group on the basis of the control group given Zhibai dihuangwan eight pills/time,threetimes a day,continuous treatment for fourweeks.Observation and comparison of two groups of patients before and after treatment of interleukin-10(IL-10),tumor necrosis factor alpha(TNF-α),the patient's vaginal health score and the level of clinical efficacy.Results compared with before treatment,IL-10,TNF-α levels were decreased after treatment of the two groups,the difference is statistically significant(P<0.05); Compared with the control group,IL-10,TNF-α is low of patients in the experimental group,the difference has statistical significance(P< 0.05);Compared with before treatment,the patients in the two groups of vagina health score were significantly increased after treatment,the difference is statistically significant(P<0.05); Compared with the control group,the vagina health score is higher in experimental group patients,the difference is statistically significant(P< 0.05); Compared with the control group,the the total efficiency is higher of patients in the experimental group,the difference is statistically significant(P<0.05).Conclusion fluconazole capsule combined with Zhibaidihuangwan can reduce trichomonad vaginitis patients serum IL-10,TNF-α levels,improve clinical symptoms,clinical curative effect is better.
关键词
氟康唑胶囊/知柏地黄丸/滴虫性阴道炎/IL-10/TNF-αKey words
fluconazole capsules/Zhibaidihuang wan/trichomonas vaginitis/IL-10/TNF-α引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据