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参芪扶正注射液治疗老年慢性心力衰竭的临床疗效及安全性

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目的 探讨参芪扶正注射液治疗老年慢性心力衰竭的临床疗效及安全性.方法 选取2014年9月~2015年9月平阳县中医院收治的58 例老年慢性心力衰竭患者,随机分为对照组及试验组,各29 例;对照组给予常规治疗,试验组在对照组基础上加用参芪扶正注射液250 mL,每天1 次,静脉滴注;比较2 组患者治疗前后血清肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)水平、治疗有效率及安全性.结果 治疗后,与对照组比较,试验组患者血清TNF-α及IL-1β水平较低(P<.0.05).试验组的治疗有效率为93.11%显著高于对照组的65.52% (P<.0.05).结论 参芪扶正注射液能够显著降低老年慢性心力衰竭患者的血清TNF-α及IL-1β水平,减轻炎症反应,提高临床疗效,且安全性较高.
The clinical curative effect and safety of Shenqifuzheng injection in the treatment of elderly patients with chronic heart failure
Objective To evaluate the clinical curative effect and safety of Shenqifuzheng injection in the treatment of elderly patients with chronic heart failure.Methods 58 cases of elderly patients with chronic heart failure were selected from September 2014 to September 2015 in our hospital and randomly divided into the control group and treatment group,29 cases in each group.The control group was given conventional therapy,on the basis of the control group,the experimental group was treated with Shenqifuzheng injection,250mL,one time a day,intravenous drip;Before and after treatment,compared between the two groups of patients with serum tumor necrosis factorα(TNF-α),interleukin 1β levels,efficiency of treatment and safety.Results After treatment,compared with the control group,the serum levels of TNF-α and IL-1β were lower in the experimental group(P<0.05); the treatment efficiency of the experimental group(93.11%)was significantly higher than that of the control group(65.52%,P<0.05).Conclusion The Shenqifuzheng injection can significantly reduce the serum levels of TNF-α and IL-1βin elderly patients with chronic heart failure,reduce inflammatory reaction,improve clinical efficacy,and safety was high.

Shenqifuzheng injectiongerontismchronic heart failureclinical efficacysafety

陈福军、陈力超

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平阳县中医院 中药房,浙江 温州 325401

平阳县中医院 内科,浙江 温州 325401

参芪扶正注射液 老年 慢性心力衰竭 临床疗效 安全性

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(4)
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