丹红注射液治疗老年心脏介入术后的临床效果及安全性评价

扫码查看

原文链接

NETL
NSTL
万方数据
维普

中文摘要：目的丹红注射液治疗老年心脏介入术后的临床效果及安全性评价.方法选取2013年9月～2015年7月浙江省台州市立医院收治的64 例拟行心脏介入治疗老年患者,随机分为对照组与试验组,每组各32 例,对照组术前给予阿司匹林肠溶片100 mg 口服,试验组在对照组的基础上给予丹红注射液20 mL 静脉滴注,连续用药14 日,2 组患者行心脏介入术.对照组术后给予阿司匹林肠溶片100 mg 口服,氯吡格雷75 mg 口服,试验组在对照组的基础上给予丹红注射液20 mL 静脉滴注,一个周期均为7 d,共治疗3 个周期.比较2 组临床疗效、治疗前后血清C-反应蛋白(CRP)、肌钙蛋白T(TnT)、P-选择素(Ps)、P 选择素糖蛋白配体1(PSGL-1)水平、心血管事件(cardiovascular events)以及不良反应发生情况.结果治疗后,对照组临床总有效率为71.88％,显著低于试验组的93.75％,差异有统计学意义( P<.0.05);试验组心血管事件发生率为21.88％,显著低于对照组40.63％,差异有统计学意义( P<.0.05);2 组血清C-反应蛋白、肌钙蛋白T、P-选择素及PSGL-1水平均显著降低,且试验组显著小于对照组,差异有统计学意义( P<.0.05);对照组不良反应发生率为15.63％,试验组为9.38％,差异无统计学意义.结论丹红注射液治疗老年心脏介入术后的临床疗效显著,安全性高,心血管事件发生率较低.

外文标题：Clinical effect and safety evaluation of Danhong injection in the treatment after cardiac interventional therapy

外文摘要：Objective To investigate the efficacy and cardiovascular disease of Danhong injection in the treatment after cardiac interventional therapy.Methods A total of 64 cases with cardiac intervention from September 2013 to July 2015 in our hospital were selected and divided into control group and experiment group with 32 cases in each group.Patients in the control group were given aspirin 100mg orally,and patients in the experiment group revieved Danhong injection 20mL intravenous drip qd,one times a day for 14 days.Two groups of patients underwent cardiac intervention.After the operaiton,the control group was given aspirin enteric-coated tablets 100mg orally,clopidogrel 75mg orally,and patients in the experiment group revieved Danhong injection 20mL intravenous drip qd,seven days for a course and the patients treated for three courses.The clinical efficacy,C-reactive protein(CRP),cardiac troponin T(TnT),P-selectin(Ps),PSGL-1,cardiovascular events(cardiovascular events),and adverse events were compared.Results After treatment,the clinical efficacy in experiment group was 93.75％,which significant higher than that in control group 71.88％,the difference was statistically significant(P<0.05).The rate of cardiovascular events in experiment group was 21.88％,which significant lower than that in control group 40.63％,the difference was statistically significant(P<0.05).The serum C-reactive protein,troponin T,Ps and PSGL-1 were significantly decreased in the two groups,and the experimental group was significantly smaller than the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions was 15.63％in the control group and 9.38％in the experimental group,the difference was not statistically significant.Conclusion Danhong injection treatment of elderly patients with cardiac intervention after the clinical effect is significant,high security,the incidence of cardiovascular events is low.

外文关键词：

Danhong injectioncardiac interventional therapyefficacysafety

作者：

李丽红、徐丹蕾、林杨闯

展开 >

作者单位：

浙江省台州市立医院心血管内科,浙江台州 318000

关键词：

丹红注射液心脏介入术临床效果安全性

出版年：

2017

DOI：