首页|黄柏胶囊内服联合中药熏洗治疗慢性肛裂的临床研究

黄柏胶囊内服联合中药熏洗治疗慢性肛裂的临床研究

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目的 研究黄柏胶囊内服联合中药熏洗治疗慢性肛裂的临床疗效.方法 将山东大学第二医院肛肠科在2014年1月~2016年6月期间收治的84 例慢性肛裂患者按照随机数字表法分为2 组,每组42 例.对照组给予硝酸甘油软膏联合利宁凝胶治疗,观察组给予中药熏洗联合黄柏胶囊内服.分析2 组治疗疗效、症状改善情况、VAS 评分和裂口愈合时间和肛管静息压(ARP)和直肠静息压(RRP)变化.结果 ①观察组总有效率为95.24%,显著高于对照组的78.57%( P< 0.05).②2组主要症状出血和便秘的患者比例在治疗后均较治疗前下降( P< 0.05);观察组治疗后出血和便秘的患者分别为(9.52%和11.90%),均低于对照组(28.57%和33.33%)( P< 0.05).治疗后观察组VAS评分为(1.18±0.20)分,低于对照组(2.39±0.22)分( P< 0.05),且观察组裂口愈合时间(14.92±2.05)天,也短于对照组(19.16±2.28)天( P< 0.05).④治疗后2组患者ARP和RRP分别为(7.88±0.40)和(2.61±0.31)kPa,均低于对照组(8.59±0.55)和(3.09±0.45)kPa.结论 中药熏洗联合黄柏胶囊内服较单独西药治疗能加快肛裂患者裂口愈合速度,增强治疗效果.
Clinical research on Huang Bai capsules combined with Chinese medicine fumigation on the treatment of chronic anal fissure
Objective To research the effect of Huang Bai capsules combined with Chinese medicine fumigation on treatment of chronic anal fissure.Methods 84 patients with chronic anal fissure from the second hospital of Shandong from January 2014~June 2016 were divided into two groups randomly.The control group was treated with Nitroglycerin and Lining gel and the observation group was treated with Huang Bai capsules combined with Chinese medicine fumigation.Treatment efficacy,symptom improvement,VAS score,gap healing time,ARP and RRP were compared between the two groups.Results The total effective rate in the observation group 95.24%is higher than that in the control group 78.57%(P<0.05).The proportion of bleeding and constipation after treatmen were lower than that before treatment(P<0.05).The proportion of bleeding and constipation in the observation group(9.52%and 11.90%)were lower than those in the control group(28.57%and 33.33%)(P<0.05).③ VAS score and gap healing time in the observation group were(1.18±0.20)points and(14.92±2.05)days,which were better than those in the control group(2.39±0.22)points and(19.16±2.28)days(P<0.05).④ARP and RRP in the observation group were(7.88±0.40)kPa and(2.61±0.31)kPa,which were lower than those in the control group(8.59±0.55)kPa and(3.09±0.45)kPa(P<0.05).Conclusion It can speed up crack healing and improve the effect of patients with anal fissure which Huang Bai capsules combined with Chinese medicine fumigation were used in the treatment.

Huang Bai capsulesChinese medicine fumigationchronic anal fissure

李志文、吕艳锋、崔振华、王贤仁

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山东大学第二医院 肛肠外科,山东 济南 250033

黄柏胶囊 中药熏洗 慢性肛裂

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(4)
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