舒血宁注射液联合贝那普利治疗糖尿病肾病的临床疗效观察

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中文摘要：目的观察舒血宁联合贝那普利治疗糖尿病肾病的临床疗效.方法选择60 例糖尿病肾病患者作为本次实验的研究对象,均为我院肾内科2014年1月～2015年1月收治,随机分组,对照组与观察组同时给予降糖治疗,对照组30 例给予贝那普利治疗,观察组30 例在对照组基础上给予舒血宁注射液治疗,观察临床效果.结果治疗后观察组尿β2-MG(尿β2 微球蛋白)和hs-CRP(超敏C 反应蛋白)分别为(0.38 ±0.08、6.29 ±1.40)mg/L,优于对照组(0.48 ±0.10、7.74 ±1.36)mg/L,且差异有统计学意义(P< 0.05);观察组治疗后24 h尿蛋白定量检测为(0.69±0.50)g/24 h,优于对照组(1.04±0.63)g/24 h,且差异有统计学意义( P< 0.05); 观察组患者治疗后尿微量白蛋白测定、低密度脂蛋白、血肌酐值分别为(359.2±50.3 mg/L、2.40±0.63 mmol/L、95.6±22.3 μmol/L),均优于对照组(379.8±48.3 mg/L、3.44±0.76 mmol/L、108.5±34.2 μmol/L),且差异有统计学意义( P< 0.05);观察组总显效率为90.0％,高于对照组73.0％,且差异有统计学意义( P< 0.05).结论舒血宁注射液联合贝那普利治疗糖尿病肾病的临床治疗效果确切,无明显副反应,值得临床进一步研究和应用.

外文标题：The clinical efficacy of treatment of diabetic nephropathy with Shuxuening injection combined with benazepril

外文摘要：Objective To observe the clinical efficacy of treatment of diabetic nephropathy with Shuxuening injection combined with benazepril.Methods 60 cases from January 2014 to January 2015,were randomly divided into observation group and control group of 30 patients.the control group were given benazepril treatment,observation group were based on Shuxuening injection treatment,patients were followed up and record changes related indicators.Results The urinary β2-MG and hs-CRP were after treatment(0.38±0.08,6.29±1.40)mg/L,than the control group(0.48±0.10,7.74±1.36)mg/L,and the difference was significant sex(P<0.05); after treatment observation group 24H urine protein quantitative detection of(0.69±0.50)g/24h,than the control group(1.04±0.63)g/24h,and the difference was statistically significant(P<0.05); After the observation group patients,low-density lipoprotein,serum creatinine value were(359.2±50.3mg/L,2.40±0.63mmol/L,95.6±22.3mol/L),were better than the control group(379.8±48.3mg/L,3.44±0.76mmol/L,108.5±34.2mol/L),and the difference was statistically significant(P<0.05); observation group total effective rate was 90.0％,higher than 73.0 percent,and the difference was statistically significant(P<0.05).Conclusion Shuxuening injection combined with benazepril clinical treatment of diabetic nephropathy exact,no significant side effects,is worthy of further research and application.

外文关键词：

Shuxueningbenazeprildiabetic nephropathycombination

作者：

吴广宇、颜思诗、陈学波

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作者单位：

浙江省舟山医院肾内科,浙江舟山 316000

关键词：

舒血宁贝那普利糖尿病肾病联合用药

出版年：

2017

DOI：