摘要
目的 探讨盐酸羟考酮注射液用于腹腔镜胆囊切除术后的镇痛效果及对5-羟色胺(5-hydroxytryptamine,5-HT)、一氧化氮(nitric oxide,NO)、P物质(substance P,SP)水平的影响.方法 选取2013年8月～2016年8月杭州市中医院接诊的90例择期行腹腔镜胆囊切除术的患者,通过随机数表法分为观察组和对照组,每组各45例.在切皮前,观察组静脉给予盐酸羟考酮注射液0.1 mg/kg,对照组静脉给予舒芬太尼0.2 μg/kg.比较2组患者麻醉情况、术后疼痛情况、不良反应以及术前术后5-HT、NO、SP变化.结果 2组患者在麻醉时间、手术时间、自主呼吸恢复时间、苏醒时间上比较差异无统计学意义;观察组在术后2 、4、24 h时,切口痛、内脏痛得分均比对照组低,差异有统计学意义(P<0.05);手术后,2组患者5-HT、NO、SP均发生变化,差异有统计学意义(P<0.05),但观察组结果均比对照组低,差异均有统计学意义(P<0.05);观察组术后不良反应总发生率低于对照组组,差异有统计学意义( P <0.05);观察组术后不良反应总发生率低于对照组组,差异有统计学意义( P <0.05).结论 在腹腔镜胆囊切除术患者中应用盐酸羟考酮注射液效果显著,可有效减轻5-HT、NO、SP的释放,缓解术后疼痛,安全性高.
Abstract
Objective To investigate oxycodone hydrochloride injectio in treatment of postoperative laparoscopic cholecystectomy and its effects on analgesia and levels of 5-hydroxytryptamine(5-HT),nitric oxide(NO),substance P(SP).Methods 90 patients of underwent laparoscopic cholecystectomy who received therapy from August 2013 to August 2016 in Hangzhou Tvaditional chinese Medical hospital were selected and randomly divided into observation group and control group,45 cases in each group.Before incision,the observation group were gived intravenous oxycodone hydrochloride injection 0.1mg/kg,the control group were gived intravenous sufentanil 0.2μg/kg.The changes of anesthesia,postoperative pain,adverse reactions and 5-HT,NO and SP after operation were compared between the two groups.ResultsThere was no significant difference in the anesthesia time,operation time,spontaneous breathing recovery time,wake up of time between two groups,after postoperative two,four,24 h,the scores of incision pain,visceral pain in the observation group were lower than the control group,the difference was statistically significant(P<0.05).After the operation,the levels of 5-HT,NO,SP of two groups were changed,the difference was statistically significant(P<0.05),but the results in observation group were lower than the control group,the difference was statistically significant(P<0.05),the total incidence of postoperative adverse reactions in observation group were lower than the control group,the difference was statistically significant(P<0.05).Conclusion Oxycodone hydrochloride injection is well for laparoscopic cholecystectomy,which can effectively reduce the release of 5-HT,NO,SP,relief of postoperative pain,high security.
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