氨溴特罗口服液联合匹多莫德口服液治疗小儿螨虫过敏性哮喘的临床疗效及安全性
Clinical efficacy and safety of ambrocol oral liquid combined with pidotimod oral liquid in allergic asthma in children with mite
梁志芳 1宁宏伟1
作者信息
- 1. 浙江省医疗健康集体杭州医院 儿科,浙江 杭州 310022
- 折叠
摘要
目的 探讨氨溴特罗口服液联合匹多莫德口服液治疗小儿螨虫过敏性哮喘的临床疗效及安全性.方法 选取2014年12月～2015年12月于浙江省医疗健康集体杭州医院接诊的54例螨虫过敏性哮喘患儿,随机分为对照组与试验组,每组各27例,在常规治疗基础上,对照组给予匹多莫德口服溶液10 mL,1次/天,口服;试验组在对照组基础上加用氨溴特罗口服溶液10 mL,2次/天,口服.比较2组患儿治疗前后血清白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、免疫球蛋白E(IgE)水平、治疗有效率及安全性.结果 治疗后,与对照组比较,试验组患儿血清IL-2水平较高,IL-4、IgE水平较低,差异有统计学意义(P<0.05).试验组的治疗有效率(92.59％)显著高于对照组(81.48％),差异有统计学意义( P <0.05).结论 氨溴特罗口服液联合匹多莫德口服液能够显著提高螨虫过敏性哮喘患儿的血清IL-2水平,降低血清IL-4、IgE水平,提高临床疗效.
Abstract
Objective To investigate the clinical curative effect and safety of ambrocol oral liquid combined with pidotimod oral liquid in the treatment of children with mite allergic asthma.Methods 54 cases of children with mite allergic asthma from December 2014 to December 2015 were selected and randomly divided into the control group and experimental group,27 cases in each group.On the basis of routine treatment,the control group was given pidotimod oral solution 10mL,once a day,oral; on the basis of the control group,the experimental group was treated with ambrocol oral solution 10mL,twice a day,oral.Interleukin-2(IL-2),interleukin-4(IL-4),immunoglobulin E(IgE)levels,the efficacy and safety of the two groups were measured before and after treatment.Results After treatment,compared with the control group,the serum levels of IL-2 were higher,and the levels of IL-4、IgE were lower in the experimental group,the difference was statistically significant(P<0.05),the treatment efficiency of the experimental group(92.59％)was significantly higher than that of the control group(81.48％),the difference was statistically significant(P<0.05).Conclusion The ambrocol oral liquid combined with pidotimod oral liquid can significantly improve the serum level of IL-2,and reduce the serum level of IL-4,IgE in children with mite allergic asthma,improve clinical efficacy.
关键词
氨溴特罗口服液/匹多莫德口服液/小儿/螨虫过敏性哮喘/临床疗效/安全性Key words
ambrocol oral liquid/pidotimod oral liquid/children/mite allergic asthma/clinical efficacy/safety引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据