大剂量与常规剂量布地奈德/福莫特罗粉吸入剂治疗COPD稳定期的疗效对比
Comparison of the efficacy of high dose and conventional dose of budesonide/formoterol inhalation in stable COPD
姜轶飞 1葛祥 1杨猛1
作者信息
- 1. 嘉兴市第二医院 呼吸科,浙江 嘉兴 314000
- 折叠
摘要
目的 比较大剂量与常规剂量布地奈德/福莫特罗粉吸入剂治疗慢性阻塞性肺疾病(chronic obstructive pulmonarydisease,COPD)稳定期的疗效与安全性.方法 选取2015年3月～2016年3月嘉兴市第二医院收治的120 例COPD 稳定期患者,均予布地奈德/福莫特罗粉吸入剂治疗,按剂量不同分为常规剂量组与大剂量组,每组各60 例.治疗前后分别进行肺功能测试、CAT 中文版量表(COPD assessment test)评估及6 min 步行距离(6 MWD)测试,并观察不良反应及急性发作情况.结果 2 组治疗后第1 s 用力呼气容积(forced expiratory volume in 1,FEV1)/用力肺活量(forced vital capacity,FVC)(FEV1/FVC)、FEV1％均明显改善,大剂量组明显优于常规剂量组,差异均有统计学意义(P<.0.05);大剂量组心悸、心动过速等不良反应明显多于常规剂量组,而急性发作率明显低于常规剂量组,差异有统计学意义( P<.0.05).结论 大剂量布地奈德/福莫特罗粉吸入剂治疗COPD稳定期患者能更好地改善肺功能及健康状态,但不良反应增多.
Abstract
Objective To compare large dose or conventional dose of budesonide/formoterol fumarate powder in treatment of stable chronic obstructive pulmonary disease(COPD).Methods 120 patients with stable COPD from March 2015 to March 2016 in Jiaxing Second hospital were selected,were treated with budesonide/formoterol,and were divided into the conventional dose group and high dose groupaccording to different doses,60 cases in each group.Pulmonary function tests,CAT Chinese version scale assessment and 6 min walking distance(6MWD)test were performed before and after treatment,and adverse reactions and acute attack were observed.Results FEV1/FVC and FEV1％were significantly improved after treatment in the two groups,and those in the high dose group were significantly better than those in the conventional dose group,the difference was statistically significant(P<0.05),CAT score and 6MWD were significantly improved after treatment in the two groups,and those in the high dose group were significantly higher than those in the conventional dose group,the difference was statistically significant(P<0.05),adverse reactions such as palpitations,tachycardiain the high dose group were significantly higher than those in the conventional dose group,while the acute attack rate was significantly lower than that of the conventional dose group,the difference was statistically significant(P<0.05).Conclusion High dose of budesonide/formoterol inhalation in the treatment of patients with stable COPD powder can improve the pulmonary function and health status,but adverse reactions increase.
关键词
布地奈德/福莫特罗粉吸入剂/COPD稳定期/肺功能/不良反应Key words
budesonide/formoterol/stable COPD/pulmonary function/adverse reaction引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据